临床分离的解脲脲支原体耐药性的变迁

目的了解医院2001~2003年临床分离的解脲脲支原体耐药性的变迁,更好的指导临床合理用药。方法对2001~2003年就诊的可疑非淋菌性尿道炎(宫颈炎)患者进行解脲脲支原体的培养及药敏检测。结果2001年1 386例中解脲脲支原体培养阳性1 003例;2002年1 015例中解脲脲支原体培养阳性801例;2003年908例中解脲脲支原体培养阳性691例;米诺环素和多西环素3年中耐药性均<4%;交沙霉素的耐药性2003年显著上升;大环内酯类罗红霉素和阿奇霉素的耐药性均较高,喹诺酮类药物环丙沙星和氧氟沙星耐药性呈较高水平。结论解脲脲支原体的药物敏感性随时间的变化而变化,定期监测解脲脲支原体的耐药性十分必要。

Antibiotic Resistance Profile of Isolated Ureaplasma urealyticum

OBJECTIVE To investigate the urogenital tract Ureaplasma urealyticum infection and drug resistance profile from 2001 to 2003.METHODS The results of U.urealyticum culture and drug sensitivity tests were explored from 2001 to 2003.RESULTS From the 1 386 cases in 2001,1 003 were infected with U.urealyticum;of the 1 015 cases in 2002,801 were infected with U.urealyticum;of the 908 cases in 2003, 691 were infected with U.urealyticum.Among the three years,the drug resistance to doxycycline and minomycine kept lower as 4%,the drug resistance to josamycin increased greatly in 2003,the drug resistance and intermediate sensitivity to roxithromycin and azithromycin were high;and the drug resistance to ofloxacin,ciprofloxacin and spectinomycin kept higher.CONCLUSIONS The drug resistance of U.urealyticum evolves with the time.Monitoring drug resistance of U.urealyticum is of great importance.Treatment for U.urealyticum infection should be based on the results of drug sensitivity tests and the pharmacokinetics of the drugs.