| FS-1272滴眼液对大鼠亚硒酸钠性白内障的影响 |
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| 引用本文： | 王晶. FS-1272滴眼液对大鼠亚硒酸钠性白内障的影响[J]. 浙江中医药大学学报, 2008, 32(2): 172-173 |
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| 作者姓名： | 王晶 |
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| 作者单位： | 浙江中医药大学,杭州,310053 |
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| 基金项目： | 上海新药研究开发中心横向课题 |
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| 摘 要： | [目的]观察FS-1272滴眼液对大鼠亚硒酸钠性白内障的作用及作用机理。[方法]采用大鼠亚硒酸钠性白内障模型,观察大鼠晶状体混浊程度,测定晶状体中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱苷肽过氧化酶(GSH-px)活性以及丙二醛(MDA)、可溶性蛋白(WSP)和不溶性蛋白(WIP)含量。[结果]FS-1272滴眼液能降低大鼠晶状体浑浊程度,增强SOD、CAT、GSH—px活性,同时降低MDA、不可溶性蛋白含量,升高可溶蛋白含量。[结论]FS-1272滴眼液可减轻晶状体氧化损伤程度,从而起到延缓白内障的发生和发展的作用。
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| 关 键 词： | 白内障 亚硒酸钠 超氧化物歧化酶 过氧化氢酶 丙二醛 谷胱苷肽过氧化酶 可溶性蛋白 不溶性蛋白 |
| 文章编号： | 1005-5509(2008)02-0172-02 |
| 修稿时间： | 2007-12-25 |
Pharmacodynamics Study of FS-1272 Gutta in Lens of Rats with Cataract Induced by Sodium Selenite |
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| Wang Jing. Pharmacodynamics Study of FS-1272 Gutta in Lens of Rats with Cataract Induced by Sodium Selenite[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2008, 32(2): 172-173 |
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| Authors: | Wang Jing |
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| Abstract: | [Objective]To study the effect and mechanism of action of FS-1272 gutta on cataract of rats induced by sodium selenite.[Method] By using themodel of cataract of rats induced by sodium selenite to observe the cataract opaque degree,the activities of SOD,CAT and GSH-px,the level of MDA,WSP and WIP.[Results] FS-1272 gutta can cause cataract opaque degree in rats decreased,the activities of SOD,CAT,GSH-px increased,and the level of MDA and insolubility protein decreased,level of solubility protein increased.[Conclusion]The FS-1272 gutta has the effect of delaying cataract to happen and develop by lessening the extent of the oxidative damage of lens. |
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| Keywords: | cataract sodium selenite SOD MDA CAT GSH-px WSP WIP |
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