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Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma |
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| Authors: | Antonio Cuadrado Aitor Orive Covadonga García-Suárez Agustín Domínguez Jose Carlos Fernández-Escalante Javier Crespo Fernando Pons-Romero |
| Affiliation: | (1) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(2) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(3) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(4) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(5) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(6) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain;(7) Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain |
| Abstract: | Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed. |
| Keywords: | OBESITY LIVER STEATOSIS HEPATOCELLULAR CARCINOMA INSULIN RESISTANCE DIABETES |
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