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Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children |
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| Authors: | B. D. Fletcher Helen E. Heslop Sue C. Kaste Sara Bodner |
| Affiliation: | (1) Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105, USA, US;(2) Departments of Radiology and Pediatrics, University of Tennessee, Memphis, Tennessee, USA, US;(3) Department of Hematology/Oncology, St. Jude Children's Research Hospital, Department of Pediatrics, University of Tennessee, Memphis, Tennessee, USA, US;(4) Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Department of Radiology, University of Tennessee, Memphis, Tennessee, USA, US;(5) Department of Pathology, St. Jude Children's Research Hospital, Department of Pathology, University of Tennessee, Memphis, Tennessee, USA, US |
| Abstract: | We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children. Received: 12 August 1997 Accepted: 11 December 1997 |
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