| 近交系NJS小鼠红细胞变形能力及其与血清胆固醇水平的关系 |
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| 引用本文： | 董政军,孙敬方.近交系NJS小鼠红细胞变形能力及其与血清胆固醇水平的关系[J].心肺血管病杂志,1998,17(1):50-52. |
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| 作者姓名： | 董政军 孙敬方 |
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| 作者单位： | 济南军区总医院!250031(董政军，潘震寰，尹秋霞，樊红)，南京军区总医院!210002(孙敬方) |
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| 摘 要： | 本文观察近交系NJS小鼠红细胞变形能力及其与血清胆固醇的关系。以DXC—300型核孔膜红细胞变形能力测定仪测定小鼠的红细胞变形指数（EFI），同时以日立7150型血液自动生化分析仪测定血清胆固醇（CHO）含量，并以C57BL／6J正常小鼠作对照。结果表明：NJS／小鼠EFI（0．29±0．06）显著高于C57BL／6J小鼠（0．20±0．10，P＜0．01），小鼠EFI与CHO水平呈正相关（r＝0．785，P＜0．01）。提示：红细胞变形能力受损可能在高胆固醇血症小鼠动脉粥样硬化的发病过程中起重要作用。
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| 关 键 词： | 红细胞变形能力 胆固醇 动脉粥样硬化 |
Relation between Erythrocyte Deformability and Cholesterol in Inbred NJS Mouse Strain |
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| Dong Zhengjun, Sun Jingfang, Pan Zhenhuan,et al..Relation between Erythrocyte Deformability and Cholesterol in Inbred NJS Mouse Strain[J].Journal of Cardiovascular and Pulmonary Diseases,1998,17(1):50-52. |
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| Authors: | Dong Zhengjun Sun Jingfang Pan Zhenhuan |
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| Institution: | Dong Zhengjun, Sun Jingfang, Pan Zhenhuan, et al. |
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| Abstract: | The relationship between erythrocyte deformability and levels of serum cholesterol (CHO) was investigated. The erythrocyte filterability index (EFI) and the levels of serum CHO of inbred NJS mouse strain with hypercholesterolemia, and C57BL/6J mouse strain (as the control group) were measured. The results showed that the EFI in NJS mouse strain (0.29±0.06) were significantly higher than those in control group(0.20±0.10, P <0.01). And there was a remarkable positive correlation between ETI and the levels Of serum CHO (r=0.785, P <0.01). It is worth mentioning that the erythrocyte deformability may play an important role in the pathogenesis of atherosclerosis in the mice with hypercholesterolemia. |
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| Keywords: | Erythrocyte deformability Cholesterol Atherosclerosis |
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