川芎嗪对大鼠脑缺血再灌注损伤的神经保护作用

目的探讨川芎嗪注射液对脑缺血再灌注损伤的防治作用。方法制备大鼠脑缺血再灌注损伤模型,随机分为假手术组、造模组、川芎嗪治疗组,观察各组大鼠神经功能损伤症状及脑组织细胞形态变化。结果脑缺血再灌注损伤后,大鼠神经功能缺损症状较重,川芎嗪80 mg/kg组在缺血再灌注损伤后12 h、1 d、3 d时间点神经行为学评分明显低于造模组(P<0.05)。川芎嗪给药各组在早期与造模组比较神经元变性坏死变化不明显,7 d后缺血周围变性神经元数量较少,细胞排列逐渐规整。结论脑缺血再灌注损伤后川芎嗪通过改善神经元变性坏死程度,缓解大鼠神经功能损伤症状,起到神经保护作用。

Neuro-protective effect of Ligustrazine in rats with cerebral ischemia reperfusion injury

Objective It is to explore the treating and preventing effect of Ligustrazine on cerebral ischemia reperfusion injury.Methods The focal cerebral ischemia reperfusion model was made by middle cerebral artery occlusion(MCAO).Male SD rats were randomly divided into sham operation,control group and Ligustrazine treatment group.Symptoms of injury of nerve function and changes of cell morphology of brain tissue were observed in every group.Results Symptoms of injury of nerve function were serious in rats after cerebral ischemia reperfusion injury.The neurological scores of TMP-treated group(80 mg/kg) at the times of 12 h, 1 d,3 d after cerebral ischemia reperfusion injury were significantly lower than that in control groups.Compared with the control group,degeneration and necrosis of nerve cells in early times were not obvious,and there were less degeneration neurons around ischemic tissue,and the cell alinement gradually became regular after 7 d in the TMP treated groups.Conclusion TMP performed neuro-protective effects by improving degeneration or necrosis degree of neurons and relieving symptoms of nerve function injury after focal cerebral ischemia-reperfusion injury.