| Abstract: | ![]()
Two cases of papular acrodermatitis of childhood (Gianotti's disease) are reported. Characteristic skin lesions and acute anicteric hepatitis associated with hepatitis B surface antigenemia were observed in each case. Subtype analysis of hepatitis B surface antigen (HBs-Ag) disclosed “adr” and “adw” respectively, which prevail among Japanese asymptomatic carriers. Intrafamilial father-to-child transmission of HB virus was strongly suspected in case 2. HBs-Ag disappeared from the serum after three months in case 1, but persisted in case 2, who also developed chronic persistent hepatitis. |
