三七皂苷改善实验性脑异常微环境及机制研究进展

三七皂苷(PNS)是五加科人参属植物三七的主要有效活性成分,含有多种单体皂苷。近年来,随着三七在临床的广泛应用,其改善缺血微环境的作用,引起了研究者的关注。该文概述了PNS调节血管、保护血管内皮细胞、消除水肿、抑制氧化应激、抑制凋亡、影响血液流变学、调节免疫等作用机制,为PNS改善实验性脑异常微环境及机制研究提供依据和新的思路,为相关研究提供参考。

Possible Mechanism of Panax Notoginseng Improve Abnormalities Microenvironment of Experiment Brain

Saponins of panax notoginseng is a mainly effective ingredient in the plant sanqi, which contains different kinds of monomer saponins. Sanqi belongs to the ginseng family. With the general application of sanqi in clinical, its function that improves the ischemia microenvironment has drew the attentions of researchers in recent years. This article summarizes the notoginsenoside efficacy in regulating blood vessels, protecting the vascular endothelial cells, eliminating edema, inhibiting oxidative stress, inhibiting apoptosis, affecting blood rheology and regulating immune function, etc, provides bases and new ideas for the researches of notoginsenoside improves abnormal microenvironment under experiment.