| 趋化因子CXCL12在缺血性脑卒中的作用及其机制 |
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| 引用本文： | 肖新兴,刘庆新.趋化因子CXCL12在缺血性脑卒中的作用及其机制[J].中华脑科疾病与康复杂志(电子版),2014(3):45-48. |
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| 作者姓名： | 肖新兴 刘庆新 |
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| 作者单位： | 滨州医学院附属医院神经内科,山东省256603 |
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| 基金项目： | 山东省医药卫生科技发展计划项目（2013wso309） |
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| 摘 要： | 趋化因子CXCL12及其受体CXCR4参与炎症反应、诱导细胞迁徙和归巢等多种生理和病理过程,且与神经的产生、内分泌及变性等均密切相关。动物实验及临床研究证明,CXCL12及其传导通路在缺血性脑卒中不同时期具有加重损伤及促进功能重建的双重作用,有可能成为预测缺血性脑卒中近期发作及预后的一个新的生物学指标,为脑卒中预防及治疗开创新的途径。
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| 关 键 词： | 趋化因子CXCL 受体 CXCR 卒中 机制 |
The role and mechanism of chemokine CXCL12 in ischemic stroke |
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| Authors: | Xiao Xinxing Liu Qingxin |
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| Institution: | . (Department of Neurology, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China) |
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| Abstract: | Chemokine CXCL12 and its receptors are participated various pathological and physiological processes, such as participated in the inflammatory response and induced cell migration and homing,etc. Moreover, CXCL12 are closely related to the generation, endocrine and degeneration of neural system,etc. Animal experiments and clinical studies have demonstrated that CXCL12 and its pathway have aggravated the injury and promotes reconstruction in the dual role of different periods of ischemic stroke, there is likely to be a new biology indicator to predict recent onset and prognosis of ischemic stroke, and to inaugurate a new way for prevention and treatment of stroke. |
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| Keywords: | Chemokine CXCL12 Receptors CXCR4 Stroke Mechanism |
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