| 乙醛脱氢酶1在胶质瘤中的研究进展 |
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| 引用本文： | 李志磊,马珠琳,张新定. 乙醛脱氢酶1在胶质瘤中的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2014, 0(1): 50-52 |
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| 作者姓名： | 李志磊 马珠琳 张新定 |
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| 作者单位： | [1]兰州大学第二临床医学院神经外科临床中心,730030 [2]兰州大学第二临床医学院,730030 |
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| 摘 要： | 胶质瘤是中枢神经系统最常见的原发性恶性肿瘤。目前,治疗的方法主要是依靠手术切除,结合术后放疗、化疗等综合治疗,但该肿瘤具有高复发率、高致死率的特点,临床疗效尚不理想,推测是因为经治疗后杀灭了大多数的肿瘤细胞,仍残留有少数肿瘤干细胞,成为复发,抵抗放、化疗的根源。乙醛脱氢酶1已被证实为多种恶性肿瘤干细胞的表面标记物,本文就乙醛脱氢酶1在胶质瘤中的研究进展作一综述。
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| 关 键 词： | 乙醛脱氢酶 神经胶质瘤 干细胞 |
Progress of aldehyde dehydrogenase 1 in gliomas |
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| Li Zhilei,Ma Zhulin,Zhang Xinding. Progress of aldehyde dehydrogenase 1 in gliomas[J]. The Chinese brain disease and rehabilitation magazine (electronic version), 2014, 0(1): 50-52 |
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| Authors: | Li Zhilei Ma Zhulin Zhang Xinding |
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| Affiliation: | . Clinical Center of Neurosurgery, the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China |
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| Abstract: | Gliomas are the most common primary central nervous system malignancy. Currently, the method of treatment relies mainly on surgery, combined with a comprehensive treatment of postoperative radiotherapy and chemotherapy, but the cancer has a high recurrence rate, characterized by a high mortality rate, the clinical effect is not ideal, presumably because of the killing after treatment most of the tumor cells, still remains a minority of cancer stem ceils to become recurrent,resistant to radiotherapy and chemotherapy root cause. Aldehyde dehydrogenase 1 has been confirmed as a variety of malignant stem cell surface markers, the research progress of ALDH1 in gliomas will be reviewed in this paper. |
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| Keywords: | Aldehyde dehydrogenase 1 Gliomas Stem cells |
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