HLA Restriction of non-HLA-A, -B, -C and -D Cell Mediated Lympholysis (CML) |
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Authors: | E. Goulmy A. Termijtelen B.A. Bradley J.J. van Rood |
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Affiliation: | Department of Immunohaematology, University Hospital, Leiden, The Netherlands |
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Abstract: | The aim of our study was to define target determinants other than those coded for by the classical HLA-A, -B, -C or -D loci which were responsible for killing in CML. In one of the families studied, strong evidence was found for the existence of a determinant coded for within the HLA region. CML was restricted to targets carrying the classical HLA-Bw35 and Cw4 determinants but the targets were neither HLA-Bw35 nor Cw4 themselves. We therefore concluded that this new HLA determinant was either the product of a new locus closely associated with HLA-B or that it was a product of the classical HLA-B locus which has not been recognized by serology. |
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