系统性红斑狼疮伴肝,肾损害时血浆P选择素测定意义

为探讨粘附分子Ｐ选择素在系统性红斑狼疮（ＳＬＥ）发病中的作用，本文采用ＥＬＩＳＡ法检测ＳＬＥ患者血浆Ｐ选择素含量。结果表明３０例患者血浆Ｐ选择素平均水平较正常对照明显升高（Ｐ〈０．０１）。其中ＳＬＥ伴肝、肾损害者的血浆Ｐ选择素显著高于不伴有肝、肾损害者（Ｐ〈０．０１），后者与正常对照组相比，也有显著差异。此外，ＳＬＥ患者血浆Ｐ选择素变化与血沉（ＥＳＲ）呈正相关（ｒ＝０．４６７，Ｐ〈０．０１）；但与

Significance of plasma P-selectin detection in systemic lupus erythematosus with liver and kidney lesions

Cell adhesion molecules are involved in leukocyte-leukocyte, leukocyte-endothelium and plateletendothelium interactions, important events in the pathogenesis of autoimmune diseases. To investgate therole of P-selectin in systemic lupus erythematosus (SLE), we detected plasma P-selectin in patients withSLE by ELISA. The results showed that plasma P-selectin level was significantly increased in 30 patientsthan controls (P<0. 01 ). There were an significant increase in patients with liver and kidney lesions thanthat without liver and kidney lesions (P<0. 01). Furthermore ) plasma P-selectin level in patients with SLEwere correlated with ESR (r=0. 467,P<0. 01) and were not related to CRP (P>0. 05). P-selectin plays arole in the pathogenesis of SLE and plasma P-selectin detection may be useful for evaluating the progress ofSLE.