艾司西酞普兰与阿米替林治疗抑郁症对照研究 |
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引用本文: | 李强,李永真,耿彩虹,王翠鹏.艾司西酞普兰与阿米替林治疗抑郁症对照研究[J].中国当代医药,2010,17(22):87-88. |
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作者姓名: | 李强 李永真 耿彩虹 王翠鹏 |
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作者单位: | 1. 新乡医学院第二附属医院临床心身疾病科,河南新乡,453002 2. 新乡医学院病理学教研室,河南新乡,453003 |
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摘 要: | 目的:比较艾司西酞普兰与阿米替林治疗抑郁症的疗效及安全性。方法:将50例患者随机分为两组,研究组(A组)25例,口服艾司西酞普兰治疗;对照组(B组)25例,口服阿米替林治疗。观察6周,与治疗前及治疗后第1、2、4、6周末采用汉密尔顿抑郁量表和临床疗效总评定量表评定临床疗效,不良反应量表评定不良反应。结果:治疗第6周末研究组显效率为96%,对照组显效率为92%,两组差异无统计学意义(P〉0.05),副反应研究组显著少于对照组(P〈0.01)。结论:对于抑郁症,艾司西酞普兰与阿米替林疗效相当,但艾司西酞普兰安全性好,依从性好。
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关 键 词: | 抑郁症 艾司西酞普兰 阿米替林 汉密尔顿抑郁量表 临床疗效总评定量表 副反应观察量表 |
Control study of escitalopram and amitriptyline in treatment of depression |
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Authors: | LI Qiang LI Yongzhen GENG Caihong WANG Cuipeng |
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Institution: | 1.Clinical Psychosomatic Diseases Division,the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453002,China;2.Department of Pathology in Xinxiang Medical Universerty,Xinxiang 453003,China) |
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Abstract: | Objective: To compare the clinical efficacy and safety of escitalopram and amitriptyline in treatment of depression.Methods: Randomly divided fifty patients into two groups,the study group included 25 cases and took escitalopram orally,the control group included 25 cases and took amitriptyline orally,who were all obseved 6 weeks.Before and after 1,2,4,6 weeks of treatment,evaluation of clincal effects with Hamilton's depression scale(HAMD) and clinical global impression(CGI),evaluation of side effects with Asberg.Results: On the sixth weekend,the obvious effect rate was 96% in the study group,but that was 92% in the control group,which had no significant difference(P〈0.05).The total scores of Asberg in the study group were significant lower than that in the the control group(P〈0.01).Conclusion: On treating the patients with depression,the effects of escitalopram is equvalent with amitriptyline,but escitalopram is better than amitripty-line in safety and the compliance. |
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Keywords: | Depressive disorder Escitalopram Amitriptyline Hamilton's depression scale Clinical global impression Rating scale for side effects |
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