粘附分子在直肠腺癌患者淋巴管内皮细胞的表达

为探讨癌细胞淋巴管侵润转移机理,对8 例人的直肠腺癌的癌周围组织和转移淋巴结以及5例正常人的直肠组织和淋巴结,采用免疫组织化学方法,检测ICAM-1和CEA的表达.结果显示癌周直肠组织中的淋巴管及转移的淋巴结中的淋巴管内皮细胞均有ICAM-1和CEA的表达.由此提示在癌细胞沿淋巴管转移过程中, ICAM-1和CEA是介导癌细胞和淋巴管内皮细胞稳定粘附的分子.

The Expression of Cell Adhesion Molecules on Lymphatic Endothelial Cells in Rectum Adenocarcinoma of human

This study was conducted to explore the mechanism of lymphatic dissemination and metastasis of cancer cells ;the specific aim was to investigate the expression of cells adhesion molecules on lymphatic endothelial cells. Immunohistochemical method was used. The rectum tissues and lymphnodes were taken from five normal human subjects. The cancer peripheral tissues and lymphnodes, and the metastasized lymphnodes were taken from eight patients with rectum adenocarcinoma. The result showed that the interce11ular adhesion molecule-l (ICAM 1) and carcinoma embryonic antigen (CEA) were expressed on lyrnphatic endothelial cells in cancer pekpheral tissues and metastasized lymphnode. The experession of ICAM-1 and CEA in cancer peripheral tissues and lymphnodes was much more remarkable than that in metastasized lymphnodes. These data suggest that ICAM-1 and CEA be cell adhesion molecules between cancer cells and lymphatic endothelial cells.