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| 还原型谷胱甘肽对顺铂肾毒性损伤的保护作用及其机制的研究 | |
| 引用本文： | 顾玉红,杜佳新,张博. 还原型谷胱甘肽对顺铂肾毒性损伤的保护作用及其机制的研究[J]. 中国医院用药评价与分析, 2010, 0(1): 63-65 |
| 作者姓名： | 顾玉红 杜佳新 张博 |
| 作者单位： | 哈尔滨医科大学附属肿瘤医院;哈尔滨医科大学附属第一临床医学院; |
| 摘 要： | 目的：观察还原型谷胱甘肽对顺铂所致肾毒性损伤的预防性保护作用。方法：100例癌症患者随机分成两组,比较其肾毒性。结果：以顺铂为主的联合化疗有效率均达到53%以上,化疗后对照组肾毒性损伤要高于治疗组。结论：还原型谷胱甘肽能有效地预防顺铂所致肾毒性损伤。 |
| 关 键 词： | 还原型谷胱甘肽 顺铂 肾毒性损伤 |
Mechanism of Protective Effect of Reduced Glutathione on Cisplatin-induced Nephrotoxicity |
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| GU Yu-hong,DU Jia-xin,ZHANG Bo. Mechanism of Protective Effect of Reduced Glutathione on Cisplatin-induced Nephrotoxicity[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2010, 0(1): 63-65 | |
| Authors: | GU Yu-hong DU Jia-xin ZHANG Bo |
| Affiliation: | GU Yu-hong~1,DU Jia-xin~2,ZHANG Bo~1 (1.The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China,2.The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China) |
| Abstract: | OBJECTIVE: To observe the protective effect of reduced glutathione(GSH) against cisplatin-induced nephrotoxicity.METHODS: 100 cancer patients were randomly divided into two groups,with the nephrotoxicity evaluated comparatively.RESULTS: The response rate of combination chemotherapy chiefly cisplation was above 53%, and the nephrotoxicity of control group was more severe than in the treatment group after chemotherapy.CONCLUSION: Reduced glutathione is effective in preventing against cisplantion-induced nephr... |
| Keywords: | Reduced glutathione Cisplation Nephrotoxicity |
| 本文献已被 CNKI 维普 等数据库收录！ | |