复方丙酸氯倍他索乳膏治疗寻常型银屑病

目的：观察复方丙酸氯倍他索乳膏治疗寻常型银屑病的疗效及安全性。方法：采用随机对照试验方法，将72例寻常型银屑病患者随机分试验组（复方丙酸氯倍他索乳膏组）和对照1组（迪维霜组）、对照2组（恩肤霜组），采用双盲法进行观察。结果：试验组痊愈率58.3%（14/24）、有效率100.0%（24/24）；对照1组痊愈率41.7%（10/24），有效率75.0%（18/24），对照2组痊愈率16.7%（4/24），有效率75.0%（18/24）。试验组分别与对照1组和对照2组比较，试验组痊愈率和有效率均高于对照组（P<0.05）；试验组和对照组均未发现药物局部和全身不良反应。结论：复方丙酸氯倍他索乳膏治疗寻常型银屑病安全、有效。

Combination use of clobetasol propionate and retin-A creamin treatment of psoriasis vulgaris

Objective To evaluate the efficacy and safety of a combination use of clobetasol propionate and retin A cream in the treatment of psoriasis vulgaris. Methods A randomized controlled and double blind trial was used. 72 patients were divided into trial group(combination of clobetasol propionate and retin A cream),control group 1(Diwei cream),and control group 2(Enfu cream). The efficacy and safety were observed.Results The cure rate and efficacy rate were 58 3% (14/24) and 100 0% (24/24),respectively, for trial group whereas cure rate and efficacy rate were 41 7% (10/24) and 75 0% (18/24), respectively, for control group 1 and 16 7% (14/24) and 75 0% (18/24) for control group 2. The difference was significant between various groups ( P <0 05). There were no local and general adverse effects of drugs in all groups.Conclusion A combination use of clobetasol propionate and retin A cream is effective and safe in treatment of psoriasis vulgaris.