| IL—2诱导的内皮细胞HLA—DR抗原表达 |
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| 引用本文： | 汪建,汪秀明,卢泳才,钟慧干,郭兆贵. IL—2诱导的内皮细胞HLA—DR抗原表达[J]. 中国免疫学杂志, 1988, 0(6) |
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| 作者姓名： | 汪建 汪秀明 卢泳才 钟慧干 郭兆贵 |
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| 作者单位： | 湖南医科大学药理教研室，中日友好医院临床医学研究所，北京中医学院，中日友好医院临床医学研究所，湖南医科大学药理教研室 长沙，长沙 |
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| 摘 要： | 用间接免疫荧光染色及微量细胞毒试验证实.人白细胞介素2(Interleukin 2,IL-2)脬育原代培养生长呈融汇状的人脐带静脉内皮细胞24～72小时.可诱发细胞的HLA—DR抗原表达,而内皮细胞抗原和Ⅷ因子相关抗原在这一过程仍呈阳性反应.IL-2影响内皮细胞摄取~8H-TdR和~3H-UR.同时对细胞形态也育影响。T淋巴细胞和经植物凝集素(PHA)激活的T细胞及其条件培养液也影响内皮细胞对~3H-TdR和~3H—UR的摄入.结果提示IL-2不仅可诱发内皮细胞的HLA-DR抗原表达.且影响细胞的代谢.
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| 关 键 词： | HLA-DR 白细胞介素2 内皮细胞 |
HLA-DR EXPRESSING OF CULTURED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS INDUCED BY IL-2 |
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| Wang Jian,et al Research Section of Pharmacology,Hunan Medical University. HLA-DR EXPRESSING OF CULTURED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS INDUCED BY IL-2[J]. Chinese Journal of Immunology, 1988, 0(6) |
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| Authors: | Wang Jian et al Research Section of Pharmacology Hunan Medical University |
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| Abstract: | Human umbilical vein endothelialcells were cultured in vitro.It wasfound that endothelial HLA-DR cannot be detected under the standardculturing condition.However,treatment of primary cultures withIL-2 can induce the expression ofHLA-DR antigen.The fact that theexpression of HLA-DR Ag and somemetabolic alternations by the endo-thelial cells can be induced by IL-2may have important implicationsfor regulation of immunologicalresponses and for some inflamma-tory diseases and atherosclerosis,even more for organ transplantation. |
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| Keywords: | HLA-DR IL-2 Endothelial Cell |
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