| Livin蛋白和血管内皮生长因子在肿瘤中的表达 |
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| 引用本文： | 朱立君,崔东旭. Livin蛋白和血管内皮生长因子在肿瘤中的表达[J]. 肿瘤研究与临床, 2009, 21(6): 425-427. DOI: 10.3760/cma.j.issn.1006-9801.2009.06.026 |
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| 作者姓名： | 朱立君 崔东旭 |
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| 作者单位： | 中国医科大学附属盛京医院肝胆胰肿瘤移植外科,沈阳,110004 |
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| 摘 要： | Livin是抑制凋亡蛋白家族（IAP）的新成员，在多数恶性肿瘤组织中高表达，其主要功能是抑制细胞凋亡。细胞凋亡与肿瘤细胞的发生、发展密切相关，肿瘤的生存更有赖于血管的生成。血管内皮生长因子（VEGF）是目前所知作用最强的一种促血管生长因子，几乎在所有的人体肿瘤和肿瘤细胞株中皆有表达。现就Livin和VEGF在肿瘤中的表达作一综述。
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| 关 键 词： | 血管内皮生长因子A 肿瘤 治疗 |
| 收稿时间： | 2009-02-25 |
Expression of Livin protein and vascular endothelial growth factor in tumor |
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| ZHU Li-jun,CUI Dong-xu. Expression of Livin protein and vascular endothelial growth factor in tumor[J]. Cancer Research and Clinic, 2009, 21(6): 425-427. DOI: 10.3760/cma.j.issn.1006-9801.2009.06.026 |
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| Authors: | ZHU Li-jun CUI Dong-xu |
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| Affiliation: | ZHU Li-jun, CUI Dong-xu( Department of Transplantation Surgery for Hepatopancreatobiliary Tumor, The Shengjing Hospital, China Medical University, Shenyang 110004, China) |
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| Abstract: | Livin is the inhibitor of apoptosis proteins (IAPs), a new member, in most malignant tissues of high expression, and its main function is to inhibit cell apoptosis. Apoptosis and tumor cells is closely related to the occurrence and development, more on which the survival of tumor angiogenesis. Vascular endothelial growth factor (VEGF) is one of the strongest of vascular growth factor, and almost all human tumors and tumor cell lines have over-expression of it. Livin and VEGF protein expression in tumor was summarized. |
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| Keywords: | Vascular endothelial growth factor A Neoplasms Therapy |
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