| 咪唑安定对鼠中枢杏仁核神经元电活动的影响 |
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| 引用本文： | 薛荣亮,付荣国,徐礼鲜.咪唑安定对鼠中枢杏仁核神经元电活动的影响[J].临床麻醉学杂志,2001,17(6):322-323. |
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| 作者姓名： | 薛荣亮 付荣国 徐礼鲜 |
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| 作者单位： | 1. 西安交通大学第二医院麻醉科
2. 第四军医大学口腔医学院麻醉科 |
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| 基金项目： | 国家自然资金资助项目 (NO :395 80 6 83) |
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| 摘 要： | 目的：观察咪唑安定及其拮抗药对杏仁核神经元峰电位发放频率的影响。方法：在40例小鼠脑薄片标本上对杏仁核簇神经元进行电生理全细胞膜片箍记录。结果：咪唑安定增加神经元放电频率，咪唑安定的这种作用起效迅速，作用时间短，其拮抗药氟马西尼可完全逆转现象。结论：咪唑安定兴奋大脑边缘系统杏仁核，通过与神经细胞膜上苯二氮卓受体 产生抗焦虚，催眠和镇静作用，其作用能完全被氟马西尼拮抗。
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| 关 键 词： | 苯二氮卓类 咪唑安定 杏仁核 中枢神经 神经元电位 小鼠 |
| 修稿时间： | 2000年8月16日 |
Effect of midazolam on neuronal electrical activity in the amygdaloid nucleus of the rats |
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| Xue RongLiang Fu Rongguo,Xu Lixian.Effect of midazolam on neuronal electrical activity in the amygdaloid nucleus of the rats[J].The Journal of Clinical Anesthesiology,2001,17(6):322-323. |
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| Authors: | Xue RongLiang Fu Rongguo Xu Lixian |
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| Institution: | Xue RongLiang Fu Rongguo,Xu Lixian. Department of Anesthesiology,Second Clinical Medical College,Xian Medical University,Xian 710004 CHINA |
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| Abstract: | Objective The Effect of midazolam and its antagonist on neuronal firing frequency was investigated.Methods Electrophysiology whole cell patch clamp technique was employed to record the electrical activity of fourty amygdaloid nucleus in rat slice preparations.Results Midazolam increased neuronal firing frequency, which was guicker in onset time,shorter in action duration and reversed comepletely by flumazenile.Conclusion Midazolam excits the amygdaloid neucleus of the central side system producing antianxiety,hypnosis and sedation,which can be reversed completely by flumazenile. |
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| Keywords: | Benzodiazepines Midazolam Amygdaloid neucleus |
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