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Platelet dysfunction and inhibition of multiple electrode platelet aggregometry caused by penicillin |
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| Authors: | Christian Schulz Olga von Beckerath Rainer Okrojek Nicolas von Beckerath Steffen Massberg |
| Affiliation: | 1. Institute of Medicine, University of Bergen, 5021, Bergen, Norway 2. Department of Medicine, Stavanger University Hospital, 4068, Stavanger, Norway 4. Department of Pathology, Haukeland University Hospital, Bergen, Norway 5. Section for Pathology, The Gade Institute, University of Bergen, 5021, Bergen, Norway 3. Institute of Surgery, University of Bergen, 5021, Bergen, Norway |
| Abstract: | BackgroundThe expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI).MethodsThe atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis.ResultsIn the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi.ConclusionOur results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC.Trial registrationbiobankregisteret@fhi.no1846 |
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