CD74 is a survival receptor on colon epithelial cells |
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| Authors: | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar |
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| Affiliation: | Department of Immunology Weizmann Institute of Science Rehovot 76100 Israel Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine Tel Aviv University Tel Aviv 69978 Department of Medicine Yale University School of Medicine New Haven CT 06520 United States |
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| Abstract: | AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analy... |
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| Keywords: | CD74 Migration inhibitory factor Colon epithelial cells |
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