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| 深静脉血栓患者C反应蛋白1059 G/C基因多态性的研究 | |
| 引用本文： | Wang MF,Yang LH,Yang XL,Zhang RJ,Dong CX,Hou LH,Liu XE. 深静脉血栓患者C反应蛋白1059 G/C基因多态性的研究[J]. 中国实验血液学杂志, 2011, 19(3): 769-771 |
| 作者姓名： | Wang MF Yang LH Yang XL Zhang RJ Dong CX Hou LH Liu XE |
| 作者单位： | 1. 山西医科大学第二医院血液科,山西太原,030001 2. 山西省肿瘤医院生物治疗科,山西太原,030001 |
| 基金项目： | 山西省科技攻关项目,编号20080311061-7 |
| 摘 要： | 本研究旨在探索C反应蛋白(C-reactive protein,CRP)1059G/C基因多态性在深静脉血栓(deep veinthrombus,DVT)中的分布及其临床意义。应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)基因分型技术检测61例DVT患者和60例对照组CRP1059G/C基因多态性,并统计各基因型及等位基因的频率。结果显示,病例组CRP1059G/C基因型及等位基因突变频率与对照组比较差异无统计学意义(p>0.05)。结论 :CRP1059G/C基因多态性存在一定的人种及地域差异,是否是DVT患者遗传性危险因素尚有待进一步研究。 |
| 关 键 词： | 深静脉血栓 C反应蛋白 CRP 1059G/C基因 基因多态性 |
1059 g/c gene polymorphism of C-reactive protein in patients with deep vein thrombosis |
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| Wang Mei-Fang,Yang Lin-Hua,Yang Xiao-Ling,Zhang Rui-Juan,Dong Chun-Xia,Hou Li-Hong,Liu Xiu-E. 1059 g/c gene polymorphism of C-reactive protein in patients with deep vein thrombosis[J]. Journal of experimental hematology, 2011, 19(3): 769-771 | |
| Authors: | Wang Mei-Fang Yang Lin-Hua Yang Xiao-Ling Zhang Rui-Juan Dong Chun-Xia Hou Li-Hong Liu Xiu-E |
| Affiliation: | WANG Mei-Fang,YANG Lin-Hua,YANG Xiao-Ling1,ZHANG Rui-Juan,DONG Chun-Xia,HOU Li-Hong,LIU Xiu-E Department of Hematology,Shanxi Medical University Second Hospital,Taiyuan 030001,Shanxi Province,China,1Department of Biotherapy,Shanxi Provincial Cancer Hospital |
| Abstract: | This study was aimed to investigate the distribution of 1059 G/C gene polymorphism of C-reactive protein(CRP) in deep vein thrombus(DVT) and its clinical significance.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to screen 1059 G/C polymorphism in exon 2 of C-reactive protein gene in 61 cases of DVT and 60 healthy controls.The frequency of mutation was calculated.The results showed that there was no statistical difference of 1059 G/C genotype and mutation frequency of... |
| Keywords: | deep vein thrombosis C-reactive protein 1059 G/C gene polymorphism |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |