| 骨髓微环境介导的白血病耐药机制研究进展 |
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| 引用本文： | Fu B,Ling YJ. 骨髓微环境介导的白血病耐药机制研究进展[J]. 中国实验血液学杂志, 2011, 19(3): 848-850 |
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| 作者姓名： | Fu B Ling YJ |
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| 作者单位： | 福建医科大学附属协和医院血液科,福建省血液病研究所,福建省重点实验室,福建福州,350001 |
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| 基金项目： | 省自然基金项目资助,编号C0710014 |
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| 摘 要： | 骨髓微环境由骨髓基质细胞、成骨细胞、破骨细胞及其产生的细胞外基质和细胞因子等组成.这些细胞通过分泌可溶性细胞因子和细胞外基质支持造血细胞的生长、增殖、分化.它不仅支持正常和恶性造血细胞的生长,并通过分泌可溶性细胞因子、细胞黏附作用、上调耐药基因及改变细胞周期等机制庇护白血病细胞所免于化疗药物的杀伤.本文就骨髓微环境介导...
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| 关 键 词： | 骨髓微环境 白血病 耐药性 |
Recent research advance on bone marrow microenvironment-mediated leukemia drug resistant mechanism |
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| Fu Bing,Ling Yan-Juan. Recent research advance on bone marrow microenvironment-mediated leukemia drug resistant mechanism[J]. Journal of experimental hematology, 2011, 19(3): 848-850 |
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| Authors: | Fu Bing Ling Yan-Juan |
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| Affiliation: | FU Bing,LING Yan-Juan Key Laboratory of Fujian Province,Fujian Institnte of Hematology,Department of Hematology,Fujian Medical University Union Hospital,Fuzhou 350001,Fujian Province,China |
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| Abstract: | The bone marrow microenvironment consists of bone marrow stromal cells,osteoblasts and osteoclasts which facilites the survival,differentiation and proliferation of hematopoietic cells through secreting soluble factors and extracellular matrix proteins that mediate these functions.This environment not only supports the growth of normal and malignant hematopoietic cells,but also protects them against the damage from chemotherapeutic agents through the secretion of soluble cytokines,cell adhesion,up-regulatio... |
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| Keywords: | bone marrow microenvironment leukemia drug-resistance |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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