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| 间接免疫荧光检测系统性红斑狼疮患者血清抗巨核细胞抗体 | |
| 引用本文： | Luo XY,Wu LJ,Chen L,Yang MH,Liu NT,Ku-Er B,Xie CM,Shi RG,Tang Z,Zhao Y,Zeng XF,Yuan GH. 间接免疫荧光检测系统性红斑狼疮患者血清抗巨核细胞抗体[J]. 中国实验血液学杂志, 2011, 19(3): 734-737 |
| 作者姓名： | Luo XY Wu LJ Chen L Yang MH Liu NT Ku-Er B Xie CM Shi RG Tang Z Zhao Y Zeng XF Yuan GH |
| 作者单位： | 1. 川北医学院风湿免疫研究所,四川南充,637000 2. 新疆维吾尔自治区人民医院风湿科,新疆乌鲁木齐,830000 3. 遂宁市中心医院风湿科,四川遂宁,629000 4. 北京协和医院风湿科,北京,100730 |
| 基金项目： | 卫生部重大疾病研究资助项目,编号2008BA159B02 |
| 摘 要： | 本研究通过检测系统性红斑狼疮(SLE)患者血清中抗巨核细胞抗体,以探讨SLE患者发生血小板减少的发病机制。应用间接免疫荧光法检测36例SLE伴血小板减少患者中的血清抗巨核细胞抗体,并与30例血小板正常的SLE患者和30名正常人对照。结果表明,血清抗巨核细胞抗体阳性在36例SLE伴血小板减少患者中占7例(19.4%),在30例血小板计数正常的SLE患者中有2例(6.7%),及在正常人中有1例(3.3%),后者与SLE伴患者血小板减少患者相比,差异有统计学意义p=0.046),但伴有或不伴有血小板减少的SLE患者之间差异无统计学意义(p=0.132)。结论 :SLE患者血清存在抗巨核细胞的自身抗体,并与部分患者发生血小板减少有关,应扩大病例数作出肯定结论 ,进一步了解SLE所致血小板减少的机理。 |
| 关 键 词： | 系统性红斑狼疮 血小板减少 抗巨核细胞抗体 间接免疫荧光检测 |
Detecting anti-megakaryocyte antibodies in serum of systemic lupus erythematosus patients by indirect immunofluorescence |
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| Luo Xiong-Yan,Wu Li-Jun,Chen Long,Yang Ming-Hui,Liu Ning-Tao,Ku-Er Banjiang,Xie Chuang-Mei,Shi Ran-Geng,Tang Zhong,Zhao Yan,Zeng Xiao-Feng,Yuan Guo-Hua. Detecting anti-megakaryocyte antibodies in serum of systemic lupus erythematosus patients by indirect immunofluorescence[J]. Journal of experimental hematology, 2011, 19(3): 734-737 | |
| Authors: | Luo Xiong-Yan Wu Li-Jun Chen Long Yang Ming-Hui Liu Ning-Tao Ku-Er Banjiang Xie Chuang-Mei Shi Ran-Geng Tang Zhong Zhao Yan Zeng Xiao-Feng Yuan Guo-Hua |
| Affiliation: | LUO Xiong-Yan,WU Li-Jun1,CHEN Long,YANG Ming-Hui,LIU Ning-Tao2,KU-ER Banjiang1,XIE Chuang-Mei,SHI Ran-Geng,TANG Zhong,ZHAO Yan3,ZENG Xiao-Feng3,YUAN Guo-Hua Institute of Rheumatology and Immunology,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China,1Department of Rheumatology,People Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang Uygur Autonomous Region,2Department of Rheumatology,Suining Municipal Central Hospital,Suining 629000,3Department... |
| Abstract: | This study was purposed to investigate the mechanism of thrombocytopenia in patients with systemic lupus erythematosus(SLE) through detecting anti-megakaryocyte antibodies in SLE patients.The serum anti-megakaryocyte antibodies in 36 SLE cases with thrombocytopenia were detected by using indirect immunofluorescence,the detected rerults were compared with detected results of 30 SLE cases without thrombocytopenia and 30 healthy persons.The rusults showed that the positive incidences of anti-megakaryocyte anti... |
| Keywords: | systemic lupus erythematosus thrombocytopenia anti-megakaryocyte antibody indirect immunofluorescence detection |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |