初治肺结核患者强化治疗前后血清可溶性白介素-2受体水平的变化

目的分析初治肺结核患者外周血中可溶性白介素-2受体(sIL-2R)在2个月强化治疗后的变化及其与病情的相关性,提高临床治疗水平。方法随机选择初治肺结核病人42例,正常健康对照28例,用酶联免疫吸附法(ELISA)测定肺结核病人强化治疗前后和正常对照组外周血sIL-2R的含量。结果初治肺结核患者治疗前、后外周血sIL-2R含量明显高于正常对照组(p<0.001,p<0.001)治疗组强化治疗前后外周血中sIL-2R的含量差异有显著性(p<0.01)。结论sIL-2R可作为肺结核病情监测及预后估计的一项参考指标。

Study of the levels of soluble interleukin-2 receptor in the peripheral blood of initially-treated patients with pulmonary tuberculosis

Objective To analyze the changes of soluble interleukin-2 receptor(sIL-2R) in the peripheral blood of initially-treated patients with pulmonary tuberculosis before and after two months intensification treatment,and to analyze the relationship between the contents of sIL-2R and state of illness,and to improve clinical therapy.Method 42 patients with initial pulmonary tuberculosis and 28 normal controls were randomly selected The contents of sIL-2R in the peripheral blood of the patients before and after anti-tuberculosis therapy,and of the controls were detected by enzyme linked immunosorbent assay(ELISA).Results The contents of sIL-2R of the patients before and after the treatment were markedly higher than those of the controls(p<0.001,p<0.001).The difference of the contents of sIL-2R before and after the treatment was significant(p<0.01).Conclusion The content of sIL-2R can be used as an useful referential indicator for monitoring and predicting pulmonary tuberculosis.