抗骨松胶囊对绝经后骨质疏松症患者骨痛和骨代谢影响的临床研究

目的：观察抗骨松胶囊治疗绝经后骨质疏松症的临床疗效。方法：选取80例绝经后骨质疏松症患者，随机分为2组。中药组48例给予抗骨松胶囊，钙剂组32例给予钙尔奇D，治疗6月。治疗前后采用双能X线骨密度测量仪测量腰椎L2-4的骨密度，检测血清骨钙素、抗酒石酸酸性磷酸酶5b水平，观察骨痛改善程度。结果：中药组及钙剂组经治疗6月后，L2-4骨密度均有不同程度升高，中药组治疗前后比较，差异有非常显著性意义（P〈0．01），钙剂组治疗前后比较，差异无显著性意义（P〉0．05）。治疗后2组骨密度比较，差异有非常显著性意义（P〈0．01）。治疗前2组骨钙素、抗酒石酸酸性磷酸酶5b比较，差异均无显著性意义（P〉0．05）。中药组治疗前后比较，骨钙素差异有非常显著性意义（P〈0．01），抗酒石酸酸性磷酸酶5b差异有显著性意义（P〈0．05）。钙剂组治疗前后比较，差异均无显著性意义（P〉0．05）。治疗后2组骨钙素、抗酒石酸酸性磷酸酶5b比较，差异均有显著性意义（P〈0．05）。骨痛疗效总有效率中药组为89．58％，钙剂组为59．38％，2组比较，差异有显著性意义（P〈0．05）。疼痛缓解平均时间中药组10～14天，钙剂组30天左右。结论：抗骨松胶囊治疗绝经后骨质疏松症疗效显著可靠。

Effect of Anti-osteoporosis Capsule on Ostealgia and Bone Metabolism of Postmenopausal Osteoporosis Patients

Objective： To observe the clinical effect of anti-osteoporosis capsule on postmenopausal osteoporosis patients. Methods： Eighty postmenopausal osteoporosis patients were randomized into two groups. The Chinese medicine group （n=48） was given anti-osteoporosis capsule for 6 months, and calcium-treated group （n=32） was given caltrate D for 6 months. Before and after treatment bone mineral density（BMD）of lumbar spine （L2-4） was measured by Dual energy X-ray. Serum osteocalcin （DXA）, tartrate-resistant acid phosphatase 5b （TRACP-5b） were assayed with absorptiometer, and ostealgia relief was also evaluated. Results： After treatment for 6 months, BMD was increased in both groups, the differences being significant （P 〈 0.01） in Chinese medicine group while insignificant in calcium-treated group（P 〉 0.05）. The difference of BMD between two groups was significant（P 〈 0.01）. Before treatment there were no significant differences of DXA and TRACP-5b between two groups（P 〉 0.05）. DXA was remarkably improved in Chinese medicine group（P 〈 0.01） and TRACP-5b was also improved（P 〈 0.05）. In calcium-treated group the differences of DXA and TRACP-5b were insignificant before and after treatment（P 〉 0.05）. After treatment the differences of DXA and TRACP-5b between two groups were significant （P 〈 0.05）. The total effective rate for ostealgia relief was 89.58% in Chinese medicine group, and was 59.38% in calcium-treated group, the difference between two groups being significant （P 〈 0.05）. The mean time for ostealgia relief was 10 to 14 days in Chinese medicine group and almost 30 days in calcium-treated group. Conclusion.. The anti-osteoporosis capsule is effecitve and safe for the treatment of postmenopausal osteoporosis.