Bioavailability of a pediatric amlodipine suspension |
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| Authors: | Dorothy?A.?Lyszkiewicz,Zina?Levichek,Eran?Kozer,Yaron?Yagev,Myla?Moretti,Marjie?Hard,Gideon?Koren mailto:gkoren@sickkids.ca" title=" gkoren@sickkids.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada. |
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| Abstract: | ![]()
Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet. |
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