替普瑞酮加奥美拉唑和阿莫西林治疗胃溃疡73例

目的 :观察替普瑞酮在治疗胃溃疡中的作用。方法 :治疗 12 6例经胃镜证实的活动性胃溃疡伴幽门螺杆菌阳性的病人随机分为对照组 5 3例 ,给予奥美拉唑 2 0mg ,每晨 1次口服 ,同时服用阿莫西林0 .5 g ,tid ,4wk为一个疗程 ;治疗组 73例 ,除同样服用上述 2种药物外 ,加服替普瑞酮 5 0mg ,tid。 4wk后复查胃镜。结果 :治疗组胃溃疡治愈率为93%优于对照组 ( 81% ,P <0 .0 5 )。 2组病人治疗前后进行胃粘膜组织氨基己糖测定 ,治疗组治疗后氨基己糖水平 [( 18.2± 2 .1) μg/mg组织 ]明显高于治疗前 [( 14 .6± 2 .5 ) μg/mg组织 ](P <0 .0 5 ) ,而对照组则无明显变化 ,分别为 ( 14 .6± 2 .4) μg/mg组织 ,( 15 .2± 2 .6) μg/mg组织。结论 :替普瑞酮可减轻胃粘膜损伤 ,促进胃溃疡愈合

Teprenone plus omeprazole and amoxicillin in treating gastric ulcer in 73 patients

AIM: To observe the therapeutic efficacy of teprenone in treating gastric ulcer. METHODS: The control group, 53 patients which was randomized from 126 patients with active gastric ulcer and HP positive, was administered omeprazole 20 mg in the morning, and amoxicillin 0.5 g tid for 4 wk. The treatment group, 73 patients in additions to the above mentioned 2 drugs, teprenone 50 mg tid was added orally for 4 wk. RESULTS: The therapeutic efficacy of treatment group (93%) was better than that of the control (81%) (P<0.05). Hexosamine determination: The gastric mucosal hexosamine levels increase significantly after treatment [(81.2±2.1) μg/mg tissue] as compared with that before treatment [(14.6±2.5) μg/mg tissue] in the treatment group, and have no significant difference in the control group [(14.6±2.4) μg/mg tissue] vs[(15.2±2.6) μg/mg tissue], respectively. CONCLUSION: The efficacy of teprenone plus omeprazole and amoxicillin can prevent the injury of gastric mucosa and promote the healing of ulcer.