Combined use of high-sensitivity C-reactive protein and apolipoprotein B/apolipoprotein A-1 ratio prior to elective coronary angiography and oral glucose tolerance tests |
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| Authors: | Wen Zhu-zhi Geng Deng-feng Luo Jin-gang Wang Jing-feng |
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| Affiliation: | aDepartment of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;bDepartment of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China |
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| Abstract: | ![]()
ObjectivesThe study aimed to investigate the predictive value of the combination of high-sensitivity C-reactive protein (hs-CRP) and apolipoprotein B (apoB)/apoA-1 ratio for the outcomes of coronary angiography (CAG), echocardiography and oral glucose tolerance tests (OGTTs).Design and methodsHs-CRP, apoB, apoA-1, and the profiles of CAG, echocardiography and OGTTs as well as traditional risk factors were measured in 1757 cardiology patients.ResultsHs-CRP or apoB/apoA-1 ratio was significantly correlated with the presence and severity of angiographic profiles, the levels of left ventricular (LV) ejection fraction, LV mass and LV mass index, and the presence of abnormal glucose metabolism. The combination of hs-CRP and apoB/apoA-1 ratio had greater correlation with abnormal glucose metabolism than its individual components in patients with normal fasting glucose, and was an independent predictor for coronary artery disease.ConclusionsThe combination of hs-CRP and apoB/apoA-1 ratio may be a strong predictor for coronary artery disease and abnormal glucose metabolism. |
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| Keywords: | Abbreviations: CAG, coronary angiography CAD, coronary artery disease OGTT, oral glucose tolerance test DM, diabetes mellitus MI, myocardial infarction hs-CRP, high-sensitivity C-reactive protein apoB/apoA-1, apolipoprotein B/apolipoprotein A-1 LV, left ventricular CVD, cardiovascular disease AGM, abnormal glucose metabolism CHF, congestive heart failure LVEDD, left ventricular end-diastolic diameter PWT, posterior wall thickness IVST, interventricular septum thickness LVM, left ventricular mass LVMI, left ventricular mass index BSA, body surface area LVH, left ventricular hypertrophy EF, ejection fraction FPG, fasting plasma glucose 2-h PG, 2-hour plasma glucose IFG, impaired fasting glucose IGT, impaired glucose tolerance TC, total cholesterol HDL-C, high-density lipoprotein cholesterol LDL-C, low-density lipoprotein cholesterol TG, triglycerides BMI, body mass index ROC, receiver operating characteristics |
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