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| 乳腺浸润性导管癌中COX-2、MMP-9的表达及临床意义 | |
| 引用本文： | 孙春雷,王祥军,周士福,时伟锋,孟东,吕庆. 乳腺浸润性导管癌中COX-2、MMP-9的表达及临床意义[J]. 现代肿瘤医学, 2010, 18(3) |
| 作者姓名： | 孙春雷 王祥军 周士福 时伟锋 孟东 吕庆 |
| 作者单位： | 苏州大学附属第四医院,江苏,苏州,214062 |
| 摘 要： | 目的:探讨COX-2和MMP-9蛋白在乳腺浸润性导管癌组织中的表达及其相关性.方法:应用免疫组织化学法检测52例乳腺癌组织COX-2和MMP-9蛋白的表达.结果:乳腺浸润性导管癌组织中COX-2阳性表达率为76.9%(40/52),MMP-9阳性表达率为82.7%(43/52),COX-2阳性表达与患者的年龄、肿瘤大小、雌孕激素受体无明显相关性(P＞0.05),而与淋巴结转移、TNM分期、组织学分级有关(P＜0.05);MMP-9阳性表达与患者的年龄、雌孕激素受体无明显相关性(P＞0.05),而与肿瘤大小、淋巴结转移、TNM分期、组织学分级有关(P＜0.05);乳腺浸润性导管癌组织中COX-2、MMP-9蛋白的表达之间存在显著正相关(r=0.448,P＜0.01).结论:乳腺浸润性导管癌组织中COX-2、MMP-9蛋白高表达,且两者具相关性.COX-2蛋白可通过诱导MMP-9蛋白的表达上调,增加乳腺癌细胞的侵袭力,促进乳腺癌浸润、转移. |
| 关 键 词： | 乳腺癌 环氧合酶-2 基质金属蛋白酶-9 |
Expression and significance of COX-2 and MMP-9 in invasive ductal carcinoma of breast |
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| SUN Chun-lei,WANG Xiang-jun,ZHOU Shi-fu,SHI Wei-feng,MENG Dong,LV Qing. Expression and significance of COX-2 and MMP-9 in invasive ductal carcinoma of breast[J]. Journal of Modern Oncology, 2010, 18(3) | |
| Authors: | SUN Chun-lei WANG Xiang-jun ZHOU Shi-fu SHI Wei-feng MENG Dong LV Qing |
| Affiliation: | SUN Chun-lei,WANG Xiang-jun,ZHOU Shi-fu,SHI Wei-feng,MENG Dong,LV Qing Department of Surgical Oncology,the Fourth Affiliated Hospital of Soochow University,Wuxi 214062,China |
| Abstract: | Objective:To study the expression and the correlation of cyclooxygenase-2(COX-2) and matrix metalloproteinase-9 (MMP-9) in invasive ductal carcinoma of breast.Methods:Expression of COX-2 and MMP-9 was detected in 52 cases of breast cancer tissue by immunohistochemistry.Results:Positive rate of COX-2 was 76.9%(40/52),positive rate of MMP-9 was 82.7%(43/52) in invasive ductal carcinoma of breast.The positive expression of COX-2 was related with lymph node metastasis,TNM stage and histological grade,but negati... |
| Keywords: | breast cancer cyclooxygenase-2(COX-2) matrix metalloproteinase-9(MMP-9) |
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