丹参注射液对老年慢性肺心病血浆内皮素及血液流变学的影响

目的探讨丹参注射液对老年慢性肺心病患者血浆内皮素(ET-1)及血液流变学的影响.方法将80例老年慢性肺心病患者随机分为两组,治疗组采用丹参注射液20mL与液体静滴,对照组采用维生素C 2.0 g 10%氯化钾5 mL 液体静滴,观察患者治疗前后血液流变学及ET-1变化.结果两组全血粘度、血浆比粘度、红细胞压积、纤维蛋白原治疗前无明显差异,疗程结束后治疗组较对照组明显为低(P＜0.05或0.01).两组血浆ET-1治疗前无明显差异,疗程结束后有显著降低(P＜0.01).结论丹参注射液对老年慢性肺心病患者血液粘度有明显降低作用,并使血浆ET-1水平显著降低.

Effect of Danshen Injection on Indexes of Hemorheoloy and Plasma Endothelin in Senile Pulmonary Heart Disease

Objective To investigate the effect of Danshen injection on indexes of hemorheology and plasma endothelin-1 in senile pulmonary heart disease. Methods 80 cases of senile pulmonary heart disease were divided into two groups randomly, treatment group and control group (conventional therapy group). Indexes of hemorheology and the level of plasma endothelin-1 in senile pulmonary heart disease were measured before and after the treatment of Danshen injection. Results No difference was found in the levels of plasma endothelin-1, blood and plasma specific viscosity, hematocrit and fibrinogen between treatment group and control group before the treatment. Compared to control group, the levels of plasma endothelin-1, blood and plasma specific viscosity, hematocrit and fibrinogen in treatment group all decreased significantly after the treatment (P<0.05 or 0.01). Conclusion Danshen injection can decrease blood viscosity and the level of plasma endothelin-1 in senile pulmonary heart disease.