Progressive multifocal leukoencephalopathy secondary to JC virus infection after liver transplantation and treatment of recurrent hepatitis C期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Progressive multifocal leukoencephalopathy secondary to JC virus infection after liver transplantation and treatment of recurrent hepatitis C

Authors:	Alibert Sophie Gérolami René Tammam David Borentain Patrick Tissot-Dupont Hervé Zandotty Christine Hardwigsen Jean Stefaniescu Mona Barrantes Carlos Le Treut Yves-Patrice Botta-Fridlund Danièle

Affiliation:	1. Service d’Hépato-Gastroentérologie, Hôpital de la Conception, Marseille;2. Service de Maladies Infectieuses, Hôpital de la Conception, Marseille;3. Service de Chirurgie Digestive et de Transplantation Hépatique, Hôpital de la Conception, Marseille;4. Service de Neurologie, Hôpital de la Timone, Marseille;5. Laboratoire de Virologie, Hôpital de la Timone, Marseille;1. Department of Internal Medicine, Temple University Hospital, Philadelphia, PA;2. Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA;1. Molecular Physiology and Therapeutics Branch, National Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, Maryland;2. North Sichuan Medical College, Sichuan, China;3. Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois;1. Department of Cancer Medicine, Gustave Roussy, Villejuif, France;2. Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France;3. CESP, INSERM, Univ. Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif, France;4. Université Paris-Sud, 15 Rue Georges Clemenceau, 91400 Orsay, France;1. Division of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Great Neck, New York, USA;1. Karmanos Cancer Institute, Wayne State University, Detroit, MI;2. Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI;1. Internal Medicine Unit, Grenoble University Hospital, Grenoble, France;2. Centre Régional de Pharmacovigilance, Grenoble University Hospital, Grenoble, France;3. Endocrinology Unit, Grenoble University Hospital, Grenoble, France;4. General Neurology Unit, Psychiatry and Neurology Department, Grenoble University Hospital, Grenoble, France

Abstract:	Progressive multifocal leucoencephalopathy due to JC virus is a rare complication of liver transplantation. Only four cases have already been described in the literature. This disease is difficult to differentiate from leucoencephalopathy associated with immunosuppressive drugs such as cyclosporin or tacrolimus. Positive diagnosis of progressive multifocal leucoencephalopathy no longer requires cerebral biopsy. It must be confirmed by positive JC virus RNA amplification in the cerebrospinal fluid. We report a case of progressive multifocal leucoencephalopathy occurring 18 months after liver transplantation for hepatitis C-related cirrhosis.

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