洛赛克及凝血酶联合治疗危重患儿应激性溃疡出血的观察及护理

目的 探讨洛赛克联合凝血酶治疗危重病儿应激性溃疡出血的临床疗效及护理对策.方法 将65例应激性溃疡出血的危重病儿随机分为洛赛克、凝血酶联合治疗组和对照治疗组.治疗组35例,其中男20例,女15例,年龄(4±2)岁和对照组30例,其中男20例,女10例,年龄(2.9±1.8)岁.2组均给予病因、对症及支持治疗,同时治疗组给予洛赛克每天0.3～0.6 mg·kg～,每日1次.并给予凝血酶每次200～500 U,每日4～6次,口服或经胃管注入,连用3～5 d.对照组给予西咪替丁每日10～20 mg·kg-1,口服或灌胃,连用3～5 d.观察应激性溃疡出血临床好转情况,同时加强护理并观察不良反应的发生情况.结果 治疗组:显效51.4%,有效40%,无效8.6%,总有效91.4%;对照组显效23.3%,有效50%,无效26.7%,总有效73.3%,2组相比有显著性意义(P＜0.01).结论 通过及时的预防及细致周到的护理,洛赛克联合凝血酶治疗危重病儿应激性溃疡疗效显著,且不良反应少.

The observation and nursing of omeprazole and thrombin in treatment stress ulcer hemorrhage of children

Objective To explore the clinical efficacy and the nursing methods of omeprazole and thromo bin for stress ulcer hemorrhage in children crisis disease. Methods Sixty - five patients with stress peptic ulcer hemorrhage were randomly divided into the omeprazole and thrombin group (thirty -five patients, M 20, F 15;age 4a + s2a) and the control group (thirty patients, M20, F10; age 2. 9a + s18a) . On basis of same therapy conditions in both groups. Treatment group received omeprazole 0. 3 ～ 0. 6 mg/kg, o or ilo, qd, and thrombin 200 -500 U po or iR, q4 -6h, for 3 ～5 d. Control group was given eimetidine 10 -20 mg,/kg, po or ip, qd for 3- 5d: and at the same time, we observed the improvement of stress ulcer hemorrhage and adverse reactions. Results The clinical total effective rate, remarkable effective rate, effective rate and ineffeetixe rate were 91.4%, 51.4%, 40%, and 8. 6% in omeprazole group and those in control group were 73.3%, 23.3%,50% and 26. 7%, respectively. There was a very significant difference between two groups ( P < 0. 01 ) . Conclusion Omeprazole and thrombin have obviously effective in treating stress ulcer hemorrhage in children crisis disease. There were no obvious adverse reactions.