53例轻度侧脑室增宽胎儿临床评估及预后的回顾性分析

目的评估胎儿轻度侧脑室增宽诊断在临床处置与预后判断中的意义。方法回顾分析2009年1月至2010年12月本中心经彩超检查发现的53例轻度侧脑室增宽胎儿的临床资料(超声、MRI、脐血染色体检查),随访出生后婴儿情况并进行临床评估及分析。结果经B超诊断轻度侧脑室增宽胎儿53例,发生率为0.5%(53/10 485);胎儿轻度侧脑室增宽合并其他结构畸形的发生率37.7%;轻度侧脑室增宽胎儿合并染色体异常发生率为9.4%。行MRI检查39例,与超声结果相符34例,符合率为87.2%。活产33例(62.3%),25例生长发育正常(75.8%)。结论超声及MRI对筛查胎儿脑室异常具有重要诊断价值,对于高龄孕妇及伴发其他结构异常的轻度侧脑室增宽建议行染色体核型分析。

Clinical evaluation and prognosis of mild ventriculomegaly in fetuses: a retrospective analysis

Objective To evaluate the importance of the prenatal diagnosis to fetus with mild ventriculomegaly(MVM)in pregnancy outcome and prognosis.Methods The ultrosonographic results of 10 485 pregnant women with a meanage of 29±6 and a pregnancy period of 22 to 34 weeks who were admitted to our hospital from Jan 2009 to Oct 2010 were collected in this study.The clinical data of fetuses with mild ventriculomegaly,including the results of ultrasonography,magnetic resonance imaging(MRI) and chromosome examination were retrospectively analyzed.Follow-up was done upon live fetus after delivery.Results Ultrasonography indicated there were 53 fetuses with mild ventriculomegaly,with an incidence rate of 0.5%(53/10 485).Forty of them were detected in the pregnancy period of 22 to 28 weeks,and the left were identified in the 28 weeks later,even in 34 weeks.The incidence of MVM complicated with other abnormities was 37.7%,and that complicated with chromosome disorder was 9.4%.Thirty-nine fetuses with MVM were examined by MRI,and thirty-four results of MRI were consistent with ultrasound results,with a consistence rate of 87.2%.There were 33 infants born live(62.3%),and 25 of them were in normal growth and development,accounting for 75.8%.Conclusion Ultrasonography and MRI play an important role in the detection of MVM.Chromosome analysis should be carried out for elder pregnant women when their fetuses are diagnosed as MVM and other complicating abnormities.