| HBV—Pre—C区段变异患者血清HBVDNA和前S1抗原的检测 |
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| 引用本文： | 张海谱 李仕英 谢晓民 张丽娜. HBV—Pre—C区段变异患者血清HBVDNA和前S1抗原的检测[J]. 中原医刊, 2006, 33(4): 1-2 |
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| 作者姓名： | 张海谱 李仕英 谢晓民 张丽娜 |
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| 作者单位： | 白求恩国际和平医院 河北石家庄050082 |
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| 摘 要： | 目的探讨HBVDNA和前S1抗原(Pre-S1)在HBV-Pre-C区段变异株感染者中的临床应用价值。方法102份乙型肝炎患者血清标本,按HBeAg阳性、HBeAg阴性且HBV-Pre-C区段(nt1896)变异阳性和HBeAg阴性且HBV-Pre-C区段(nt1896)变异阴性分为三组,分别对Pre-S1和HBVDNA进行检测分析。结果HBV-Pre-C区段变异阳性组Pre-S1和HBVDNA检测结果与HBeAg阳性组比较无统计学意义(P>0.05);HBV-Pre-C区段变异阴性组Pre-S1和HBVDNA与HBeAg阳性组比较差异有统计学意义(P<0.01)。结论Pre-S1与HBVDNA在评价HBV复制上有高度的一致性,在检测HBV-Pre-C区段变异患者时有相似的应用价值。
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| 关 键 词： | 前S1抗原 乙型肝炎病毒DNA 变异 |
| 收稿时间： | 2005-10-31 |
| 修稿时间： | 2005-10-31 |
The detection of serum HBVDNA and Pre -S1 in patients with HBV precore mutant |
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| ZHANG Haipu, LI Shiying, XIE Xiaomin, ZHANG Lina. The detection of serum HBVDNA and Pre -S1 in patients with HBV precore mutant[J]. Central Plains Medical Journal, 2006, 33(4): 1-2 |
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| Authors: | ZHANG Haipu LI Shiying XIE Xiaomin ZHANG Lina |
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| Affiliation: | The Bethune International Peace Hospital, Shijiazhuang 050082, Hebei |
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| Abstract: | Objective To explore the value of HBVDNA and Pre-S1 in patients with HBV precore mutant.Methods 102 serum samples of type B hepatitis,dividd in to three groups according to HBeAg positive,HBeAg negative and HBV-Pre-C segment mutation positive or negative,separately detected and analyzed the HBVDNA and Pre-S1.Results The HBVDNA and Pre-S1 results of group HBV-Pre-C segment mutation positive had no significant difference with HBeAg positive(P>0.05),but group HBV-Pre-C segment mutation negative had significant difference with HBeAg positive(P<0.01).Conclusions HBVDNA and Pre-S1 have high consistency in evaluating HBV duplication,and have semblation applicable value in detecting HBV-Pre-C segment mutation. |
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| Keywords: | Pre-S1 HBVDNA Mutant |
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