DJ-1基因g.168185del多态性与新疆维吾尔族、汉族帕金森病的关系

目的探讨DJ-1基因启动子区多态性位点g.168₁85del与新疆维吾尔（维）族、汉族帕金森病（PD）的关系。方法提取364例原发性PD患者（PD组,维族175例,汉族189例）及346名正常对照者（正常对照组）基因组DNA,采用PCR方法扩增DJ-1启动子区基因片段,测序验证g.168₁85del的基因型和等位基因频率。结果 PD组与正常对照组间、PD组中维族亚组与汉族亚组间〗DJ-1基因g.168₁85del基因型及等位基因频率差异无统计学意义。结论 DJ-1基因g.168₁85del多态性可能与维族及汉族PD的遗传易感性无关。

Association between the polymorphism of DJ-1 gene g.168_185del and Parkinson's disease in Xinjiang Uygurs and Hans

Objective To explore the association between the polymorphism of DJ-1 gene’s promoter region g.168₁85del and Parkinson’s disease（PD） in Xinjiang Uygurs and Hans.Methods The genetic DNA was extracted from 364 PD patients（PD group,175 Uygur cases and 189 Han cases） and 346 normal controls（NC group）.The gene fragments of DJ-1 gene’s promoter region were amplified by PCR.The frequencies of gene type and allele of g.168₁85del were identified by DNA sequencing.Results The frequencies of g.168₁85del genotype and allele between PD and NC groups,also PD Uygur and Han subgroups were no significant difference.Conclusion The polymorphism of DJ-1 gene g.168₁85del may be not associated with genetic predisposition of PD in Uygur and Han Nationality.