脑出血患者血清超敏C反应蛋白水平与出血量、病情及认知功能损害的关系

目的探讨脑出血患者血清超敏C反应蛋白(hs-CRP)水平与出血量、病情及认知功能损害的关系。方法 56例脑出血患者(脑出血组)根据血肿体积分为小血肿亚组(<15 ml,23例)、中血肿亚组(15～30 ml,18例)和大血肿亚组(>30 ml,15例);根据入院时美国国立卫生研究院卒中量表(NIHSS)评分分为轻度亚组(≤7分,19例)、中度亚组(8～14分,21例)和重度亚组(≥15分,16例);检测患者发病后第1、3、7 d及30名正常对照者(正常对照组)血清hs-CRP水平;脑出血患者血肿吸收后进行简易精神状态检查(MMSE)量表评分。结果脑出血组发病后1、3、7 d血清hs-CRP水平明显高于正常对照组(均P<0.001);并且在小、中、大血肿亚组间及病情轻、中、重亚组间依次显著升高(P<0.05～0.001);出现认知功能障碍患者血清hs-CRP水平显著高于无认知功能障碍患者(P<0.001)。结论血清hs-CRP水平升高越明显,提示患者脑出血量大、神经功能缺损程度重,并可能发生认知功能损害。

Relationship between level of serum high-sensitivity C-reactive protein with hemorrhage volume,condition and cognitive impairment in patients with intracerebral hemorrhage

Objective To explore the relationship between the level of serum high-sensitivity C-reactive protein(hs-CRP)with hemorrhage volume,condition and cognitive impairment in patients with intracerebral hemorrhage(ICH).Methods Acording to the hemorrhage volume 56 ICH patients(ICH group) were divided into small hematoma subgroup(<15 ml,23 cases),medium hematoma subgroup(15-30 ml,18 cases)and large hematoma subgroup(>30 ml,15 cases);and acording to the score of the national institutes of health stroke scale(NIHSS) were divided into condition mild subgroup(≤7,19 cases),moderate subgroup(8-14,21 cases) and severe subgroup(≥15,16 cases).The levels of serum hs-CRP in ICH patients at 1,3,7 d after onsets and 30 normal controls(NC group) were detected.The cognitive function of ICH patients was examined by mini-mental state examination(MMSE) scale after hematoma absorption.Results The levels of serum hs-CRP in ICH group at 1,3,7 d after onset were significant higher than that in the NC group(all P<0.001);and which was significantly higher in turn among the small,medium and large hematoma subgroups;and also condition mild,moderate and severe subgroups(P<0.05-0.001).The level of serum hs-CRP in ICH patients with cognitive dysfunction was signifcant higher than the ICH patients without cognitive dysfunction(P<0.001).Conclusion The serum level of hs-CRP in ICH patients is more obvious rise,which prompt that the hemorrhage volume larger,neurological deficiency degree more serious,and possible with cognitive impairment.