| 巨噬细胞移动抑制因子对2型糖尿病患者血管病变的影响 |
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| 引用本文： | 倪正平,张建,巴荣,雷艳花,金星进,王建娟,陆益龙.巨噬细胞移动抑制因子对2型糖尿病患者血管病变的影响[J].江苏医药,2012,38(3):275-277. |
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| 作者姓名： | 倪正平 张建 巴荣 雷艳花 金星进 王建娟 陆益龙 |
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| 作者单位： | 倪正平 (丹阳市人民医院内科, 江苏省,212300) ； 张建 (江苏大学附属医院) ； 巴荣 (江苏大学附属医院) ； 雷艳花 (江苏大学附属医院) ； 金星进 (南通大学附属妇幼保健院内科) ； 王建娟 (南通大学附属妇幼保健院内科) ； 陆益龙 (江苏大学附属医院) ； |
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| 摘 要： | 目的探讨2型糖尿病(T2DM)患者血清巨噬细胞移动抑制因子(MIF)水平变化及其对糖尿病血管病变的影响。方法用ELISA法检测T2DM合并血管病变患者(A组,19例)、T2DM无血管病变患者(B组,19例)和健康体检者(C组,16例)血清MIF和超敏C反应蛋白(hs-CRP)。同时检测血糖(BG)和糖化血红蛋白(HbA1c)。结果 A组和B组MIF、hs-CRP水平均高于C组(P<0.01)。A组hs-CRP与血糖呈正相关。B组MIF与hs-CRP、BG水平呈正相关,hs-CRP与BG、HbA1c水平呈正相关。结论糖尿病血管病变患者MIF与hs-CRP高表达是促进血管病变发生的重要因素。
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| 关 键 词： | 2型糖尿病 糖尿病血管病变 巨噬细胞移动抑制因子 超敏C反应蛋白 |
Effect of serum macrophage migration inhibitory factor on type-2 diabetes-related angiopathy |
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| Institution: | NI Zhengping,ZHANG Jian,BA Rong,et al.Department of Internal Medicine,Danyang People′s Hospital,Danyang 212300,CHINA |
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| Abstract: | Objective To investigate the changes of the serum contents of macrophage migration inhibitory factor(MIF) and its effect on the development of angiopathy in the patients with type-2 diabetes mellitus(T2DM).Methods Serum MIF and high-sensitivity C-reactive protein(hs-CRP) were detected with ELISA in 19 T2DM cases with angiopathy(group A)and 19 T2DM without angiopathy(group B) and 16 healthy persons(group C).The contents of blood glucose(BG) and glycosylated hemoglobin A-1c(HbA1c) were tested as well.Results Serum levels of MIF and hs-CRP were higher in groups of A and B than those in group C.Serum hs-CRP was positively correlated to BG in group A.Serum MIF was positively correlated to hs-CRP and BG,and hs-CRP was positively correlated with BG and HbA1c in group B.Conclusion High expressions of MIF and hs-CRP are the important factors to promote the development of angiopathy in the patients with T2DM. |
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| Keywords: | Type 2 diabetes mellitus Diabetic angiopathy Macrophage migration inhibitory factor High-sensitivity C-reactive protein |
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