COPD急性加重期患者血清IL-8与C反应蛋白变化及临床意义

目的 观察COPD急性加重期患者治疗前、后血清IL-8与C反应蛋白（CRP）的变化。方法 确诊为COPD急性加重期的36例患者治疗前、后及36例健康成人外周血液，采用酶联免疫法测定IL-8，散射比浊法测定C反应蛋白。结果COPD急性加重期患者治疗前IL-8水平为1．929±1．705ng／L，治疗后1．304±1．520ng／L，治疗后明显降低（P〈0．01）；CRP治疗前56．1±32．08mg／L，治疗后7．3±2．06mg／L，治疗后显著降低（P〈0．01）。结论 IL-8、CRP参与了COPD急性加重期的炎症反应，是判断有无急性感染的参考指标。

Clinical significance of the level of serum IL-8 and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease

Objective To study the level of serum concentration of interlinkin-8(IL-8)andC-Reaction protein in patiens with acute exacerbationl of chronic obstructive pulmonary diseases(COPD )before and after two weeks therapy. Methods The serum was sample and prepared from 36 cases of COPD patients with acute exacerbation before and after two weeks therapy and 36 normal controls.serum level of IL-8 was detected by ELISA and CRP by nephelometry method. Results The level of IL-8 in COPD with acute exacerbation is significantly higher than that after therapy (P<0.01)and in control group (P<0.01);the level of CRP in acute exacerbation is significantly higher than that in control group(P<0.01).Conclusion IL-8 and CR being involved the acute inflammation in COPD may be indication of infection in COPD patienes.