Term neonatal encephalopathy antecedent cerebral palsy: A retrospective population-based study |
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| Affiliation: | 1. Division of Pediatric Neurology, Montreal Children''s Hospital-McGill University Health Center, Montreal, Quebec, Canada;2. Department of Neurology & Neurosurgery, McGill University, Canada;3. Department of Pediatrics, McGill University, Canada;4. Research Institute, Montreal Children''s Hospital, Canada;1. School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4001, Australia;2. School of Applied Science, Engineering and Health, RMIT, Melbourne, VIC 3001, Australia;3. Premion, The Wesley Medical Centre, Suite 1, 40 Chasely St, Auchenflower, QLD 4066, Australia;4. Australian Radiation Protection and Nuclear Safety Agency, 619 Lower Plenty Road, Yallambie, VIC 3085, Australia;1. Department of Neurology & Neurosurgery, McGill University, Canada;2. Department of Pediatrics, McGill University, Canada;1. VU University Medical Center, Department of Rehabilitation Medicine, Postbus 7057, 1007 MB Amsterdam, The Netherlands;2. Maastricht University Medical Center+, Department of Neurology, Postbus 5800, 6202 AZ Maastricht, The Netherlands;3. VU University Medical Center, Department of Neurosurgery, Postbus 7057, 1007 MB Amsterdam, The Netherlands;4. Maastricht University Medical Center+, Department of Orthopedic Surgery, Postbus 5800, 6202 AZ Maastricht, The Netherlands;1. Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, School of Medicine, Beer Sheva, Israel;2. Center of Clinical Research, Ben Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel;3. Department of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Policlinico di Bari, Universita’ degli Studi di Bari “Aldo Moro”, School of Medicine, Bari, Italy;1. Department of Medicine, Pontifícia Universidade Católica de Goiás (PUC Goiás), Goiânia, GO, Brazil;2. Genetics Master Program, Pontifícia Universidade Católica de Goiás (PUC Goiás), Goiânia, GO, Brazil;3. Laboratory of Oncogenetics and Radiobiology, Associação de Combate ao Câncer, Goiás, Goiânia, GO, Brazil |
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| Abstract: | ![]()
ObjectiveTo compare the clinical profile of term-born cerebral palsy children with or without antecedent moderate to severe neonatal encephalopathy. We hypothesized that antecedent neonatal encephalopathy is associated with a spastic quadriparesis cerebral palsy clinical profile, a higher severity of functional motor impairment, and a greater number of associated comorbidities.MethodsUsing the Quebec Cerebral Palsy Registry, neurologic subtype, Gross Motor Function Classification System stratification, and comorbidities were compared in children with cerebral palsy with and without antecedent neonatal encephalopathy. Differences between groups were evaluated using chi square analysis for categorical variables and student t test for continuous variables.ResultsWe identified 132 children with cerebral palsy born full term over a 4 year-interval (1999–2002 inclusive) within the Quebec Cerebral Palsy Registry, of which 44 (33%) had an antecedent neonatal encephalopathy. Spastic quadriplegia subtype of cerebral palsy and Gross Motor Function Classification System Level III–V (non-independent ambulation) were significantly associated with antecedent neonatal encephalopathy. The mean number of comorbidities experienced was not different in the two groups. Of five documented comorbidities, only severe communication difficulties were found to be associated (p < 0.05) with antecedent neonatal encephalopathy.ConclusionA pattern of increased neuromotor impairment, functional gross motor severity and possible communication difficulties was found in the 33% of children with cerebral palsy born at term and with a history of neonatal encephalopathy. |
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