环氧化酶2在肾癌组织中表达及与血管生成的关系

目的：探讨环氧化酶2（COX-2）在肾癌组织中表达的意义及其与血管生成的关系.方法：采用免疫组化法检测34例肾癌组织和癌周正常肾组织中COX-2的表达及微血管密度（MVD）.结果：COX-2在肾癌组织中表达的阳性率为76.47%,癌周正常肾组织中表达的阳性率为13.33%,两者比较有统计学意义（P＜0.01）.COX-2的异常表达与肾癌的病理分级及临床分期之间的差异无统计学意义.COX-2表达阳性组的MVD高于COX-2表达阴性组,两者之间有显著相关性（r=0.75,P＜0.01）.结论：COX-2的异常表达可能与肾肿瘤的发生有关,可为肾肿瘤的治疗和预防开辟新的途径.

Expression of cyclooxygenase-2 and its association with angiogenesis in renal cell carcinoma

Objective: To study the significance of cyclooxygenase-2 (COX-2) expression and its association with angiogenesis in renal cell carcinoma. Methods: Immunohistochemical method was performed to detect COX-2 expression and mcirovessel density (MVD) in 34 cases of renal cell carcinonma and 15 peritumor normal tissues. Results: The positive expression rate of COX-2 was 76.47% in renal cell carcinoma and 13.33% in peritumor normal tissues ( P <0.01). No association between COX-2 expression and both pathological grades and clinical stages was found ( P >0.05). The MVD in COX-2 positive tumors was significantly higher than that in COX-2 negative tumors ( P <0.01), and there is a strong association between COX-2 expression and MVD ( r =0.75, P <0.01). Conclusion: Aberrant COX-2 expression may play an important role in the occurrence of renal cell carcinoma.