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| 肾移植受者新发恶性肿瘤后免疫抑制方案的调整 | |
| 引用本文： | 苗芸,于立新,邓文锋,付绍杰,徐健,杜传福,王亦斌,叶桂荣,张新科,周敏捷. 肾移植受者新发恶性肿瘤后免疫抑制方案的调整[J]. 中华移植杂志(电子版), 2011, 5(3): 21-25 |
| 作者姓名： | 苗芸 于立新 邓文锋 付绍杰 徐健 杜传福 王亦斌 叶桂荣 张新科 周敏捷 |
| 作者单位： | 南方医科大学南方医院器官移植科,广州,510515 |
| 基金项目： | 2010年广东省自然科学基金(0451051501005789); 2010年广东省医学科研基金(B2010196) |
| 摘 要： | 目的总结肾移植后新发恶性肿瘤患者免疫抑制治疗方案的调整经验。方法分析1978年1月至2011年6月期间3279例肾移植受者中67例新发恶性肿瘤患者的临床资料。结果术后新发恶性肿瘤中,泌尿生殖系统恶性肿瘤最为常见（56.7%）。予以外科手术与免疫抑制剂减至半量或将钙调磷酸酶抑制剂转换为雷帕霉素相结合的个体化治疗方案。5年患者存活率为30%。结论对于移植后新发肿瘤患者,宜采取外科手术与免疫抑制剂减量或换药相结合的个体化治疗方案。 |
| 关 键 词： | 肾移植 恶性肿瘤 免疫抑制 个体化治疗 |
Immunosuppressive therapy for kidney transplant recipients with de novo cancers |
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| MIAO Yun , YU Li-xin , DENG Wen-feng , FU Shao-jie , XU Jian , DU Chuan-fu , WANG Yi-bin , YE Gui-rong , ZHANG Xin-ke , ZHOU Min-jie. Immunosuppressive therapy for kidney transplant recipients with de novo cancers[J]. Chinese Journal of Transplanation(Electronic Version), 2011, 5(3): 21-25 | |
| Authors: | MIAO Yun YU Li-xin DENG Wen-feng FU Shao-jie XU Jian DU Chuan-fu WANG Yi-bin YE Gui-rong ZHANG Xin-ke ZHOU Min-jie |
| Affiliation: | MIAO Yun,YU Li-xin,DENG Wen-feng,FU Shao-jie,XU Jian,DU Chuan-fu,WANG Yi-bin,YE Gui-rong,ZHANG Xin-ke,ZHOU Min-jie.Department of Organ Transplantation,Nan Fang Hospital,Southern Medical University,Guangzhou 510515,China |
| Abstract: | Objective To summarize the immunosuppressive therapy for kidney transplant recipients who developed cancers after transplantation.Method De novo cancer data in 67 transplant recipients during January 1978 to June 2011 were collected.Result Overall incidence rate for de novo malignancy posttransplantation was 2.0%(67/3279).Cancers derived from urinary and reproductive organs were the most common(56.7%).Most recipients were treated by surgery and were administered with reduced dose of immunosuppression agents... |
| Keywords: | Kidney transplantation Malignancy Immunosuppression Individualized therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |