红霉素衍生物抗菌活性构效关系研究进展

为解决抗生素的耐药性问题，近年来在红霉素化学结构修饰方面开展了大量的研究，并发现了诸如酮内酯、酰内酯、双环内酯等多种具有良好抗耐药菌活性的新型大环内酯类化合物。该文对红霉素衍生物抗菌活性研究成果做一概括，并对构效关系研究的某些重要结论加以探讨。

Recent development in the structure-activity relationships for the antimicrobial activity of erythromycin derivatives

To address the problem of antibiotic resistance, tremendous efforts had been devoted to the chemical modification of erythromycin during the past several years. As a consequence, several novel series of macrolides, such as ketolide, acylide, bicyclolide, etc., had been recognized to be highly effective against macrolide-resistant pathogens. In this review, the recent progress on the antimicrobial research area of erythromycin derivatives were summarized and some important conclusions regarding structure-activity relationships were also discussed.