临床药师在呼吸内科干预抗生素应用的效果评价

目的:评价临床药师在呼吸内科干预抗生素应用的效果。方法:选择2010年6月-2013年6月到我院呼吸内科住院使用抗生素的患者为研究对象,分为对照组(无临床药师派驻)与干预组(派驻临床药师,对临床用药进行监管),每月分别从两组使用抗生素的出院病例中随机抽取30份病历为研究对象,每组病例1 110份,分别予以评价抗生素使用强度(AUD)及合理性、抗生素不良反应、抗生素成本效益。结果:对照组与干预组抗生素AUD分别为230 DDDs/100人/天、170 DDDs/100人/天,联用率分别为28.47%、11.17%,使用合理率分别为71.98%、93.69%,副作用发生率分别为10.72%、2.07%,平均住院时间分别为(17.15±4.27)d、(11.47±3.46)d,抗生素疗程分别为(14.31±4.52)d、(9.19±3.23)d,抗生素费用分别为(7 348.19±1 047.25)元、(4 612.14±931.57)元。结论:临床药师在呼吸内科进行干预后,抗生素使用更加合理,副作用减少。

Interventional Effects of Clinical Pharmacists against Antibiotics Use in Department of Respiratory Medicine

OBJECTIVE： To evaluate the effect of clinical pharmacists intervening in antibiotics use in department of respirato- ry medicine. METHODS： The patients who used antibiotics and admitted in respiratory department of our hospital during Jun. 2010--Jun. 2013 were studied and divided into control group （no clinical pharmacists accredited） and intervention group （clinical pharmacists accredited to supervise the clinical drug use）. 30 discharged patients who used antibiotics were randomly collected from each group every month respectively, with 1 110 cases in each group. The AUD and rationality of antibiotics, the antibiotics-in- duced ADR, the cost of antibiotics were evaluated, respectively. RESULTS： The AUD of control group and intervention groups were 230 DDDs/100 persons/day and 170 DDDs/100 persons/day, respectively. The rates of combined use of antibiotics were 28.47% and 11.17% ; reasonable rates were 71.98% and 93.69%, respectively. The incidences of side effects were 10.72% and 2.07%, respectively; average hospitalization stay were （17.15 ±4.27）d and （11.47± 3.46）d, respectively. The treatment course of antibiotics were （14.31 ± 4.52） d and （9.19 ± 3.23） d, respectively. Antibiotics costs were （7 348.19 ± 1 047.25） yuan and （4 612.14 ± 931.57） yuan, respectively. CONCLUSIONS： After the intervention of clinical pharmacist in department of respiratory medicine, there is more rational use of antibiotics and less side effects.