红细胞COMT活性与情感障碍的相关性研究

目的分析红细胞COMT活性与情感障碍的关系,探讨情感障碍发病的生化机制.方法采用高效液相色谱法测定112例情感障碍患者和120例健康正常人红细胞中COMT的活性,用SPSS统计软件对测定结果进行检验比较.结果患者组及对照组男女性别间COMT活性差异无显著性(P >0.05), 患者组COMT活性频率分布在2～23 nmol/ml RBC/hr范围,对照组为7～28 nmol/ml RBC/hr范围.患者组COMT平均活性为(11.0±3.8)nmol/ml RBC/hr,对照组COMT平均活性为(16.1±4.3)nmol/ml RBC/hr.男性患者COMT为(11.2±3.7)nmol/ml RBC/hr,女性患者(10.6±4.0) nmol/ml RBC/hr,对照组男性(16.5±4.6)nmol/ml RBC/hr,女性(15.4±3.9)nmol/ml RBC/hr,患者组和对照组以及按男女性别区分COMT活性的差异均具非常显著性(P <0.001).结论情感障碍患者红细胞COMT活性低于正常人,提示红细胞COMT活性的降低与情感障碍有关.

Association study of erythrocytes catechol-O-methyltransferase activity and mood disorders

Objective To analyse the relationship between catechol-O-methyltransferase (COMT) activity and affective disorders, and explore the biological mechanism of the etiology of affective disorders.Methods The activities of erythrocytes COMT from 112 affective disorders and 120 normal control were measured with high performance liquid chromatography, all examined data were tested by SPSS 11.0v.Results COMT activity frequency distribution of patients group and control group are at the range of 2～23nmol/ml RBC/hr and 7～28nmol/ml RBC/hr respectively. The average activity of COMT in patients group and control group were (11.0±3.8) nmol/ml RBC/hr and (16.1±4.3) nmol/ml RBC/hr representatively. COMT activity in male and female patient were (11.2±3.7) nmol/ml RBC/hr and (10.6± 4.0) nmol/ml RBC/hr., male and female in control group were (16.5 ±4.6) nmol/ml RBC/hr and (15.4±3.9) nmol/ml RBC/hr, there were significant difference between patients group and control group and also between male and female (P <0.001).conclusion The activity of erythrocytes COMT in affective disorders is lower than normal population and suggested that the lower COMT activity of erythrocytes is associated with affective disorders.