| 新型免疫检查点HHLA2在人肺腺癌中的表达及其临床意义 |
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| 引用本文： | 南方圆,陈梦茜,陈洪雷.新型免疫检查点HHLA2在人肺腺癌中的表达及其临床意义[J].数理医药学杂志,2019(10):1426-1428. |
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| 作者姓名： | 南方圆 陈梦茜 陈洪雷 |
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| 作者单位： | 武汉大学基础医学院病理学教研室;武汉市江夏区人民医院胸外科 |
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| 摘 要： | 目的:免疫检查点在包括人肺腺癌(lung adenocarcinoma,LUAD)的免疫治疗中取得了突破性进展,而HHLA2(Human endogenous retrovirus-H long terminal repeat-associating protein 2,人内源性逆转录病毒H长末端重复结合蛋白2)是最近发现的免疫调节分子B7同源家族的成员。本文研究HHLA2在LUAD中的表达情况和临床意义。方法:采用免疫组化方法检测74例LUAD患者及相应的癌旁组织中HHLA2的表达情况。结果:与癌旁组织相比, HHLA2在LUAD的肿瘤组织中显著过表达(P<0.05),但并未发现与其他临床病理参数的相关性。结论:HHLA2与肺腺癌的发生有关,是潜在的免疫治疗靶点。
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| 关 键 词： | HHLA2 肺腺癌 免疫检查点 |
Expression and Clinical Significance of New Immune Checkpoint HHLA2 Protein in Human Lung Adenocarcinoma |
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| Nan Fangyuan,Chen Mengxi,Chen Honglei.Expression and Clinical Significance of New Immune Checkpoint HHLA2 Protein in Human Lung Adenocarcinoma[J].Journal of Mathematical Medicine,2019(10):1426-1428. |
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| Authors: | Nan Fangyuan Chen Mengxi Chen Honglei |
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| Institution: | (Department of Pathology,Basic Medical College of Wuhan University,Wuhan 430000;Department of Thoracic Surgery,Wuhan Jiangxia People's Hospital,Wuhan 430000) |
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| Abstract: | Nan Fangyuan;Chen Mengxi;Chen Honglei(Department of Pathology,Basic Medical College of Wuhan University,Wuhan 430000;Department of Thoracic Surgery,Wuhan Jiangxia People's Hospital,Wuhan 430000) |
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| Keywords: | HHLA2 lung adenocarcinoma immune checkpoint |
| 本文献已被 CNKI 维普 等数据库收录！ |
