酒精性肝病合并乙型肝炎病毒感染60例临床分析

目的 通过对郑州大学第一附属医院5年收治的60例酒精性肝病(ALD)合并乙型肝炎病毒(HBV)感染患者的临床资料分析,研究其临床特点和危险因素,以提高大众对酒精性肝病合并乙型肝炎病毒感染的认识及增加对戒酒等健康生活习惯的重视.方法 分析60例酒精性肝病合并乙型肝炎病毒感染患者的临床资料,并以100例单纯酒精性肝病患者、100例单纯乙型肝炎病毒感染患者为对照组,比较组间疾病严重程度,评价3组的治疗效果,分析酒精性肝病合并乙型肝炎病毒感染发病类型的危险因素.结果 (1)合并组实验室指标升高明显高于对照组(P＜0.05).(2)治疗4周后合并组治疗效果较两对照组差(P＜0.05).(3)通过Logistic回归分析表明,危险因素OR值为平均每日饮酒量＞HB-DNA定量＞饮酒年限＞吸烟＞年龄.结论 乙型肝炎病毒感染可加重酒精性肝病患者病情,降低治疗效果；每日饮酒量、饮酒年限、HBV-DNA定量、吸烟、年龄均为二者合并时的危险因素；因此对于酒精性肝病合并乙型肝炎病毒感染患者通过戒酒,培养良好生活方式是预防肝功能损伤加重、改善疾病疗效及预后的重要积极措施.

Clinical Analysis of 60 Cases of Alcoholic Liver Disease with Hepatitis Virus B Infection

Objective To analyze the clinical data of 60 patients with alcoholic liver disease(ALD) with hepatitis virus B(HBV)infection in the first affiliated hospital of Zhengzhou university in recent 5 years,and to study the clinical characteristics and risk factors,so as to improve public awareness of ALD with HBV infection and pay more attention to healthy habits including abstinence.Methods Patient group including 60 patients with ALD with HBV infection,compared with 100 patients with simple ALD and 100 patients with simple HBV infection.Severity of disease was compared between groups and treatment effect of three groups was evaluated.The relevant factors of ALD with HBV infection were analyed.Results(1)The clinical laboratory indexes in ALD with HBV infection group were significantly higher compared with the simple ALD group and the simple HBV infection group.(2)After 4 weeks treatment,decline in those clinical laboratory indexes of ALD with HBV infection group was significantly lower than the simple ALD group and the simple HBV infection group.(3)By means of Logistic regression analysis,the odds ratio(OR)was:daily drinking>HBV-DNA quantitative>the duration of drinking>smoking>age.Conclusion HBV infection may worsen the ALD patients condition and may increase the hospitalization days.Many risk factors(daily drinking,the duration of drinking;HBV-DNA quanutative,smoking,age)will influence the condition of the disease;therefore develop good lifestyle for ALD patients with HBV infection through abstinence is an impotrant and positive measure for prevention of liver dysfunction increased and improvement of treatment effect and prognosis.