Vasodilator effects of C-type natriuretic peptide on cerebral arterioles in rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Vasodilator effects of C-type natriuretic peptide on cerebral arterioles in rats

Authors:	Yoshimasa Mori Masakazu Takayasu Yoshio Suzuki Masato Shibuya Jun Yoshida and Hiroyoshi Hidaka

Institution:	^a Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466, Japan ^b Department of Pharmacology, Nagoya University School of Medicine, Nagoya, Japan

Abstract:	The vasodilator effects of C-type natriuretic peptide (CNP) were investigated in isolated rat cerebral arterioles. CNP caused dose-dependent vasodilation, maximally by 10.0±2.2% at 10^?6 M. The median effective concentration (EC₅₀) was 5.2×10^?10 M. In contrast, atrial natriuretic peptide and B-type natriuretic peptide, other members of the natriuretic peptide family, produced little or no vasodilation. Pretreatment with methylene blue (10^?4 M) abolished CNP-induced vasodilation, whereas pretreatment with N^G-monomethyl- Full-size image -arginine or indomethacin did not inhibit vasodilation. Thus, CNP is suggested to cause significant vasodilation in cerebral arterioles via a cyclic guanosine monophosphate-dependent mechanism. © 1997 Elsevier Science B.V. All rights reserved.

Keywords:	CNP (C-type natriuretic peptide) BNP (brain natriuretic peptide) ANP (atrial natriuretic peptide) Cerebral arteriole
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