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| 水杉总黄酮对肾性高血压大鼠左室肥厚的作用 | |
| 引用本文： | 刘惟莞,曾加雄,石明健,杨晓茹,糜留西,郑庆安,卢云英,王红英. 水杉总黄酮对肾性高血压大鼠左室肥厚的作用[J]. 中草药, 2000, 31(11): 837-839 |
| 作者姓名： | 刘惟莞 曾加雄 石明健 杨晓茹 糜留西 郑庆安 卢云英 王红英 |
| 作者单位： | 武汉大学医学系药理学教研室(430071);武汉大学医学系药理学教研室(430071);武汉大学医学系药理学教研室(430071);武汉大学医学系药理学教研室(430071);中科院武汉植物研究所;中科院武汉植物研究所;武汉大学医学系药理学教研室(430071);武汉大学医学系药理学教研室(430071) |
| 基金项目： | 国家自然科学基金资助项目:项目号39770088 |
| 摘 要： | 目的:研究水杉总黄酮对肾性高血压大鼠左室肥厚的预防作用。方法:二肾一夹法建立大鼠肾性高血压心肌肥厚模型, 术后第4周, 不同剂量的水杉总黄酮 ig给药, 持续5周。结果:水杉总黄酮(400, 40 mg/ kg.d)能显著降低 HW/BW、LVW/BW、心肌纤维直径、左心室肌 Ca2+含量, 对大鼠收缩压无显著性影响。结论:水杉总黄酮对肾性高血压大鼠左室肥厚有预防作用, 机制可能与钙拮抗作用有关。 |
| 关 键 词： | 木杉总黄酮 高血压 左室肥厚 |
Effects of Total Flavone of Metasequoia glyptostroboides on Left Ventricular Hypertrophy in Renovascular Hypertensive Rats |
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| Liu Weiwan,Zeng Jiaxiong,Shi Mingjian,Yang Xiaoru,Lu Yunying,Wang Hongying,Mi Liuxi and Zheng Qing''an. Effects of Total Flavone of Metasequoia glyptostroboides on Left Ventricular Hypertrophy in Renovascular Hypertensive Rats[J]. Chinese Traditional and Herbal Drugs, 2000, 31(11): 837-839 | |
| Authors: | Liu Weiwan Zeng Jiaxiong Shi Mingjian Yang Xiaoru Lu Yunying Wang Hongying Mi Liuxi Zheng Qing''an |
| Affiliation: | Department of Medicine, Wuhan University (Wuhan 430071);Department of Medicine, Wuhan University (Wuhan 430071);Department of Medicine, Wuhan University (Wuhan 430071);Department of Medicine, Wuhan University (Wuhan 430071);Wuhan Institute of Botany, Chinese Academy of Sciences;Wuhan Institute of Botany, Chinese Academy of Sciences;Department of Medicine, Wuhan University (Wuhan 430071);Department of Medicine, Wuhan University (Wuhan 430071) |
| Abstract: | The effects of total flavone of Metasequoia glyptostroboides Hu et Cheng (TFM) on left ventricular hypertrophy in rat were investigated. Left ventricular hypertrophy of rat was induced by renovascular hypertension, and then treated by ig TFM for five weeks. results showed that TFM (400, 40 mg/kg/d) markedly reduced HW/BW, LVW/BW, left ventricular Ca2+ content and myofibril diameter, but without effect on systolic blood pressure (SBP). In conclusion, TFM can prevent left ventricular hypertrophy in renovascular hypertensive rats The mechanism of action may be related to its calcium antagonistic properties |
| Keywords: | total flavone of Metasepuoia glyptostroboides Hu et Cheng hypertension left ventricular hypertrophy |
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