|
|||||
|
|
| VEGF、VEGFR-2和MVD在肾上腺皮质癌中的表达及意义 | |
| 引用本文： | 祝宇,吴瑜璇,赵菊平,何竑超,袁菲,张俊,芮文斌,张翀宇,计骏,孙福康,周文龙,谢欣,沈周俊,金晓龙. VEGF、VEGFR-2和MVD在肾上腺皮质癌中的表达及意义[J]. 现代泌尿外科杂志, 2010, 15(5): 329-331 |
| 作者姓名： | 祝宇 吴瑜璇 赵菊平 何竑超 袁菲 张俊 芮文斌 张翀宇 计骏 孙福康 周文龙 谢欣 沈周俊 金晓龙 |
| 作者单位： | 1. 上海交通大学医学院附属瑞金医院泌尿外科,上海,200025 2. 上海交通大学医学院附属瑞金医院病理科,上海,200025 3. 上海交通大学医学院附属瑞金医院普外科,上海,200025 |
| 基金项目： | 上海市自然科学基金资助 |
| 摘 要： | 目的探讨VEGFR-2、VEGF和MVD在肾上腺皮质癌(ACC)中的表达及其临床意义。方法选取经手术治疗且具有完整的临床、病理资料的肾上腺皮质肿瘤存档石蜡标本37例,其中良性组20例,恶性组(ACC组)17例。采用免疫组化技术,检测良、恶性肾上腺皮质肿瘤中VEGFR-2、VEGF和MVD的表达情况。结果 VEGFR-2在ACC组中呈高表达(76.47%),在良性组中表达较低(25.00%),ACC组与良性组之间VEGFR-2的表达有显著性差异(P0.05)。VEGF在ACC组中呈高表达(70.59%),在良性组中表达较低(25.00%),VEGF在ACC组中的表达与在良性组中的表达有显著性差异(P0.05)。MVD在ACC组中的表达为(76.40±15.64),良性组中为(21.05±8.07),两者之间有显著性差异(P0.05)。结论 VEGFR-2和VEGF以及MVD在ACC中的高表达为抗肿瘤血管生成治疗在ACC中的应用,提供了一定的理论依据。 |
| 关 键 词： | 肾上腺皮质癌 血管内皮生长因子受体2（VEGFR-2） 血管内皮生长因子（VEGF） 微血管密度（MVD） 免疫组织化学 |
Relationship of VEGF, VEGFR-2 and MVD expressions in adrenal cortical carcinoma |
|
| ZHU Yu,WU Yu-xuan,ZHAO Ju-ping,HE Hong-chao,YUAN Fei,ZHANG Jun,RUI Wen-bin,ZHANG Chong-yu,JI Jun,SUN Fu-kang,ZHOU Wen-long,XIE Xin,SHEN Zhou-jun,JIN Xiao-long. Relationship of VEGF, VEGFR-2 and MVD expressions in adrenal cortical carcinoma[J]. Journal of MOdern Urology, 2010, 15(5): 329-331 | |
| Authors: | ZHU Yu WU Yu-xuan ZHAO Ju-ping HE Hong-chao YUAN Fei ZHANG Jun RUI Wen-bin ZHANG Chong-yu JI Jun SUN Fu-kang ZHOU Wen-long XIE Xin SHEN Zhou-jun JIN Xiao-long |
| Affiliation: | 1.Department of Urology,2.Department of Pathology,3.Department of General Surgery,Ruijin Hospital,Medical School of Shanghai Jiaotong University,Shanghai 200025,China) |
| Abstract: | Objective To investigate the expressions of VEGF,VEGFR-2 and microvessel density（MVD）in adrenal cortical carcinoma（ACC）as well as to discuss the clinical significance.Methods 37 adrenal cortical neoplasm specimens resected from patients were examined by immunohistochemistry for the expressions of VEGF,VEGFR-2 and MVD.The patients were divided into two groups（20 benign cases and 17 malignant cases）.Results VEGFR-2 expressed highly in the ACC group（76.47%）and lowly in the benign group（25.00%）,with significant difference（P0.05）.VEGF expressed highly in the ACC group（70.59%）and lowly in the benign group（25.00%）,with significant difference（P0.05）.MVD expressed highly in the ACC group（76.40±15.64）and lowly in the benign group（21.05±8.07）,with significant difference（P0.05）.Conclusions The high expression of VEGF and VEGFR-2 in ACC contributed to tumor angiogenesis,which provided the theoretical evidence for anti-angiogenesis regime in ACC. |
| Keywords: | adrenal cortical carcinoma vascular endothelial growth factor receptor-2 vascular endothelial growth factor microvessel density immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |